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Rat Monoclonal to CD41 (mouse) / Platelet GPIIb

MWReg30 (IgG1)

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  11-763-C025 purified 0.025 mg yes choose region PDF datasheetHTML datasheet buy
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Background

CD41 (platelet glycoprotein IIb) is composed of two subunits (120 kDa a, alpha and 23 kDa b, beta) that interact with CD61 in the presence of calcium to form a functional adhesive protein receptor. Upon blood vessel damage, this receptor binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin. CD41 is mainly expressed on megakaryocyte-platelet lineage, but generally belongs to the antigens that are expressed during early stages of hematopoietic differentiation.

Specificity

The rat monoclonal antibody MWReg30 recognizes CD41 (GPIIb), a transmembrane glycoprotein (integrin family) composed of two chains GPIIb alpha (heavy chain; 120 kDa) and GPIIb beta (light chain; 23 kDa). CD41 is mainly expressed on platelets and megakaryocytes.

Regulatory Status

Immunogen

Murine platelets

Species Reactivity:

  • Mouse

Negative Species:

Applications:

  • Flow Cytometry
  • Immunoprecipitation
  • Immunohistochemistry (paraffin sections)
  • Immunohistochemistry (frozen sections)
  • ELISA
  • Functional Application
    platelet depletion
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

Product Specific References

  • *Brancaleone V, Gobbetti T, Cenac N, le Faouder P, Colom B, Flower RJ, Vergnolle N, Nourshargh S, Perretti M: A vasculo-protective circuit centered on lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 operative in murine microcirculation. Blood. 2013 Jul 25;122(4):608-17. [Abstract] [Full Text]
  • *Boisset JC, Clapes T, Van Der Linden R, Dzierzak E, Robin C: Integrin αIIb (CD41) plays a role in the maintenance of hematopoietic stem cell activity in the mouse embryonic aorta. Biol Open. 2013 Apr 11;2(5):525-32. [Abstract] [Full Text]
  • *Sullivan BP, Wang R, Tawfik O, Luyendyk JP: Protective and damaging effects of platelets in acute cholestatic liver injury revealed by depletion and inhibition strategies. Toxicol Sci. 2010 May;115(1):286-94. [Abstract] [Full Text]
  • *Ramsey H, Zhang Q, Brown DE, Steensma DP, Lin CP, Wu MX: Stress-induced hematopoietic failure in the absence of immediate early response gene X-1. Haematologica. 2013 Sep 20. [Epub ahead of print] [Abstract]
  • For research use only. Not for drug, diagnostic or other use.

    Example Data

    MWReg30 PE

    Fig. 1. Surface staining of CD41 on murine thrombocytes with anti-CD41 (MWReg30) PE.

    Unless indicated otherwise, all products are For Research Use Only and not for diagnostic or therapeutic use. Not for resale or transfer either as a stand-alone product or as a component of another product without written consent of EXBIO. EXBIO will not be held responsible for patent infringement or other violations that may occur with the use of our products. All orders are accepted subject to EXBIO´s term and conditions which are available at www.exbio.cz.
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