Rat Monoclonal to CD5 (mouse)
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(T1) is a single-chain transmembrane glycoprotein expressed on all mature T-lymphocytes, most of thymocytes, subset of B-lymphocytes and on many T-cell leukemias and lymphomas. It is a type I membrane glycoprotein whose extracellular region contains three scavenger receptor cysteine-rich (SRCR) domains. CD5 modulates signaling through the antigen-specific receptor complex (TCR and BCR). CD5 crosslinking induces extracellular Ca++ mobilization, tyrosine phosphorylation of intracellular proteins and DAG production. CD5 may serve as a dual receptor, giving either stimulatory or inhibitory signals depending both on the cell type and development stage. In thymocytes and B1a cells seems to provide inhibitory signals, in peripheral mature T lymhocytes it acts as a costimulatory signal receptor. CD5 is the phenotypic marker of a B cell subpopulation involved in the production of autoreactive antibodies.
The rat monoclonal antibody 53-7.3 recognizes CD5, a 67kDa single-chain transmembrane glycoprotein expressed on mature T lymphocytes, most of thymocytes and B-1 lymphocytes.
mouse thymus or spleen cells
- Flow Cytometry
- Immunohistochemistry (paraffin sections)
- Immunohistochemistry (frozen sections)
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.
Product Specific References
*Wang JY, Lee J, Yan M, Rho JH, Roehrl MH: Dermatan sulfate interacts with dead cells and regulates CD5(+) B-cell fate: implications for a key role in autoimmunity. Am J Pathol. 2011 May;178(5):2168-76. [Abstract] [Full Text]
*Jeong YI, Hong SH, Cho SH, Lee WJ, Lee SE: Induction of IL-10-producing CD1dhighCD5+ regulatory B cells following Babesia microti-infection. PLoS One. 2012;7(10):e46553. doi: 10.1371/journal.pone.0046553. [Abstract] [Full Text]
*Sestero CM, McGuire DJ, De Sarno P, Brantley EC, Soldevila G, Axtell RC, Raman C: CD5-dependent CK2 activation pathway regulates threshold for T cell anergy. J Immunol. 2012 Sep 15;189(6):2918-30 [Abstract] [Full Text]
For research use only. Not for drug, diagnostic or other use.
Surface staining of murine splenocytes with anti-CD5 (53-7.3