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Mouse Monoclonal to CD161

HP-3G10 (IgG1)

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Background

CD161, also known as Nkrp1 (natural killer receptor protein 1) or Klrb1 (killer cell lectin-like receptor subfamily b member 1), is a disulphide-linked homodimeric receptor, which is involved in regulation of NK cell and NKT cell function. It is expressed on a majority of NK cells, NKT cells, and e.g. Th17 cells and CD3+ thymocytes. Although rat CD161 has three isoforms (a, b, c), the human CD161 is expressed as one isoform.

Specificity

The mouse monoclonal antibody HP-3G10 recognizes CD161, a type II transmembrane C-type lectin receptor, expressed on the plasma membrane of NK cells, dendritic cells, activated monocytes and a subset of T cells as a disulphide-linked homodimer.

Regulatory Status

Immunogen

human NK cells

Species Reactivity:

  • Human
  • Non-Human Primates

Negative Species:

Applications:

  • Flow Cytometry
  • Western Blotting
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

Product Specific References

  • *Pozo D, Valés-Gómez M, Mavaddat N, Williamson SC, Chisholm SE, Reyburn H: CD161 (human NKR-P1A) signaling in NK cells involves the activation of acid sphingomyelinase. J Immunol. 2006 Feb 15;176(4):2397-406. [Abstract] [Full Text]
  • *Germain C, Meier A, Jensen T, Knapnougel P, Poupon G, Lazzari A, Neisig A, Håkansson K, Dong T, Wagtmann N, Galsgaard ED, Spee P, Braud VM: Induction of lectin-like transcript 1 (LLT1) protein cell surface expression by pathogens and interferon-γ contributes to modulate immune responses. J Biol Chem. 2011 Nov 4;286(44):37964-75 [Abstract] [Full Text]
  • *Wong EB, Akilimali NA, Govender P, Sullivan ZA, Cosgrove C, Pillay M, Lewinsohn DM, Bishai WR, Walker BD, Ndung'u T, Klenerman P, Kasprowicz VO: Low Levels of Peripheral CD161++CD8+ Mucosal Associated Invariant T (MAIT) Cells Are Found in HIV and HIV/TB Co-Infection. PLoS One. 2013 Dec 31;8(12):e83474 [Abstract] [Full Text]
  • *Birgit Fogal, Tai Yi, Chen Wang, Deepak A. Rao, Amir Lebastchi, Sanjay Kulkarni, George Tellides, Jordan S. Pober: Neutralizing IL-6 reduces human arterial allograft rejection by allowing emergence of CD161(+) CD4(+) T regulatory cells. J Immunol. 2011 December 15; 187(12): 6268–6280. [Abstract]
  • *Tresoldi E, Dell'Albani I, Stabilini A, Jofra T, Valle A, Gagliani N, Bondanza A, Roncarolo MG, Battaglia M: Stability of human rapamycin-expanded CD4+CD25+ T regulatory cells. Haematologica. 2011 Sep;96(9):1357-65. [Abstract] [Full Text]
  • *Goetzl EJ, Huang MC, Kon J, Patel K, Schwartz JB, Fast K, Ferrucci L, Madara K, Taub DD, Longo DL: Gender specificity of altered human immune cytokine profiles in aging. FASEB J. 2010 Sep;24(9):3580-9. [Abstract] [Full Text]
  • For research use only. Not for drug, diagnostic or other use.

    Example Data

    HP-3G10 APC


    Fig. 1. Surface staining of human peripheral blood cells using anti-CD161 (HP-3G10) APC.


    1P-729


    Fig. 2. Surface staining of human peripheral blood cells using anti-CD161 (HP-3G10) PE.


    HP-3G10 pur


    Fig. 3. Surface staining of human peripheral blood cells using anti-CD161 (HP-3G10) purified, GAM-APC.

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