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Mouse Monoclonal to CD116

4H1 (IgG1)

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CD116 (GM-CSF R alpha) is the low affinity receptor for granulocyte-macrophage colony-stimulating factor (GM-CSF). CD116 heterodimerizes with CD131, the common beta chain subunit shared with IL-3 and IL5 receptors, to form the high affinity GM-CSF receptor. CD116 is expressed by myeloid cells including macrophages, neutrophils, eosinophils, dendritic cells, and their precursors, as well as on endothelial cells. It is being used as a specific marker of myeloid leukemias.


The mouse monoclonal antibody 4H1 recognizes human CD116, the GM-CSF receptor alpha subunit (approx. 80 kDa) expressed e.g. by neutrophils, eosinophils, monocytes and macrophages.

Regulatory Status


CD116-transfected COS cells

Species Reactivity:

  • Human

Negative Species:


  • Flow Cytometry
  • Immunoprecipitation
  • Western Blotting
  • Immunohistochemistry (frozen sections)
  • Mass Cytometry
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

Product Specific References

  • Stomski FC, Woodcock JM, Zacharakis B, Bagley CJ, Sun Q, Lopez AF: Identification of a Cys motif in the common beta chain of the interleukin 3, granulocyte-macrophage colony-stimulating factor, and interleukin 5 receptors essential for disulfide-linked receptor heterodimerization and activation of all three receptors. J Biol Chem. 1998 Jan 9;273(2):1192-9. [Abstract] [Full Text]
  • *Huntington ND, Legrand N, Alves NL, Jaron B, Weijer K, Plet A, Corcuff E, Mortier E, Jacques Y, Spits H, Di Santo JP: IL-15 trans-presentation promotes human NK cell development and differentiation in vivo. J Exp Med. 2009 Jan 16;206(1):25-34 [Abstract] [Full Text]
  • *Koba C, Haruta M, Matsunaga Y, Matsumura K, Haga E, Sasaki Y, Ikeda T, Takamatsu K, Nishimura Y, Senju S: Therapeutic effect of human iPS-cell-derived myeloid cells expressing IFN-β against peritoneally disseminated cancer in xenograft models. PLoS One. 2013 Jun 24;8(6):e67567 [Abstract] [Full Text]
  • *Schwarzmaier D, Foell D, Weinhage T, Varga G, Däbritz J: Peripheral monocyte functions and activation in patients with quiescent Crohn's disease. PLoS One. 2013 Apr 26;8(4):e62761. [Abstract]
  • For research use only. Not for drug, diagnostic or other use.

    Example Data

    4H1 purified MC

    Fig. 1. Surface staining (mass cytometry) of human peripheral blood with anti-CD116 (4H1) 153Eu. Gated on singlets.

    4H1 PE

    Fig. 2. Surface staining (flow cytometry) of human peripheral blood with anti-CD116 (4H1) PE.

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