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Mouse Monoclonal to CD94

HP-3D9 (IgG1)

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  11-727-C025 purified 0.025 mg yes choose region PDF datasheetHTML datasheet buy
  11-727-C100 purified 0.1 mg yes choose region PDF datasheetHTML datasheet buy
  1F-727-T025 FITC 25 tests yes choose region PDF datasheetHTML datasheet buy
  1F-727-T100 FITC 100 tests yes choose region PDF datasheetHTML datasheet buy
  1P-727-T025 PE 25 tests yes choose region PDF datasheetHTML datasheet buy
  1P-727-T100 PE 100 tests yes choose region PDF datasheetHTML datasheet buy
  1A-727-T025 APC 25 tests yes choose region PDF datasheetHTML datasheet buy
  1A-727-T100 APC 100 tests yes choose region PDF datasheetHTML datasheet buy
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Background

CD94, also known as KLRD1 (killer cell lectin-like receptor D1), is a transmembrane glycoprotein of the C-type lectin family, which forms disulfide-linked heterodimers with NKG2A, B, C, E, H proteins, constituting functionally distinct receptors of NK cells and related cell types. CD94/NKG2A and CD94/NKG2B heterodimers serve as inhibitory, whereas CD94/NKG2C and CD94/NKG2E as activating receptors. The ligand for CD94/NKG2 complexes has been identified as HLA-E. Extent of CD94 expression on NK cell surface can be used to demonstrate their progress through the differentiation process.

Specificity

The mouse monoclonal antibody HP-3D9 recognizes CD94, a 70 kDa type II transmembrane glycoprotein expressed on NK cells, NK-T cells, and subsets of CD8+ T cells and gamma/delta T cells.
HLDA V; WS Code NK82

Regulatory Status

Immunogen

Cultured human NK cells

Species Reactivity:

  • Human

Negative Species:

Applications:

  • Flow Cytometry
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

Product Specific References

  • *Romero P, Ortega C, Palma A, Molina IJ, Peña J, Santamaría M: Expression of CD94 and NKG2 molecules on human CD4(+) T cells in response to CD3-mediated stimulation. J Leukoc Biol. 2001 Aug;70(2):219-24. [Abstract] [Full Text]
  • *Wada H, Matsumoto N, Maenaka K, Suzuki K, Yamamoto K: The inhibitory NK cell receptor CD94/NKG2A and the activating receptor CD94/NKG2C bind the top of HLA-E through mostly shared but partly distinct sets of HLA-E residues. Eur J Immunol. 2004 Jan;34(1):81-90. [Abstract] [Full Text]
  • *Yu J, Mao HC, Wei M, Hughes T, Zhang J, Park IK, Liu S, McClory S, Marcucci G, Trotta R, Caligiuri MA: CD94 surface density identifies a functional intermediary between the CD56bright and CD56dim human NK-cell subsets. Blood. 2010 Jan 14;115(2):274-81 [Abstract] [Full Text]
  • *Phillips JH, Chang C, Mattson J, Gumperz JE, Parham P, Lanier LL: CD94 and a novel associated protein (94AP) form a NK cell receptor involved in the recognition of HLA-A, HLA-B, and HLA-C allotypes. Immunity. 1996 Aug;5(2):163-72. [Abstract]
  • *Seo N, Tokura Y, Ishihara S, Takeoka Y, Tagawa S, Takigawa M: Disordered expression of inhibitory receptors on the NK1-type natural killer (NK) leukaemic cells from patients with hypersensitivity to mosquito bites. Clin Exp Immunol. 2000 Jun;120(3):413-9. [Abstract]
  • *Hallermalm K, Seki K, De Geer A, Motyka B, Bleackley RC, Jager MJ, Froelich CJ, Kiessling R, Levitsky V, Levitskaya J: Modulation of the tumor cell phenotype by IFN-gamma results in resistance of uveal melanoma cells to granule-mediated lysis by cytotoxic lymphocytes. J Immunol. 2008 Mar 15;180(6):3766-74. [Abstract] [Full Text]
  • *Bovenschen HJ, Van De Kerkhof PC, Gerritsen WJ, Seyger MM: The role of lesional T cells in recalcitrant psoriasis during infliximab therapy. Eur J Dermatol. 2005 Nov-Dec;15(6):454-8. [Abstract]
  • *Ntrivalas EI, Kwak-Kim JY, Gilman-Sachs A, Chung-Bang H, Ng SC, Beaman KD, Mantouvalos HP, Beer AE: Status of peripheral blood natural killer cells in women with recurrent spontaneous abortions and infertility of unknown aetiology. Hum Reprod. 2001 May;16(5):855-61. [Abstract]
  • For research use only. Not for drug, diagnostic or other use.

    Example Data

    HP-3D9 APC


    Fig. 1. Surface staining of CD94 in human peripheral blood with anti-CD94 (HP-3D9) APC.




    HP-3D9 PE


    Fig. 2. Surface staining of CD94 in human peripheral blood with anti-CD94 (HP-3D9) PE.




    HP-3D9 purified


    Fig. 3. Surface staining of CD94 in human peripheral blood with anti-CD94 (HP-3D9) purified, GAM-APC.

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