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Mouse Monoclonal to NR2F6

EM-51 (IgG2a)

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Background

NR2F6 (Nuclear receptor subfamily 2 group F member 6), also known as EAR2 or ERBAL2, is a transcription factor involved in modulation of hormonal responses. NR2F6 represses e.g. transcription of the oxytocin-neurophysin gene, renin gene, lutropin-choriogonadotropic hormone receptor gene, and the thyroid hormone receptor gene. In the immune system, NR2F6 affects IL-17 expression in the Th-17 cells, thus also the balance between immunological tolerance and autoimmunity.

Specificity

The mouse monoclonal antibody EM-51 recognizes NR2F6, a transcriptional repressor expressed mainly in the heart, placenta, liver, skeletal muscle, kidney and pancreas, but also e.g. in T cell subpopulations.

Regulatory Status

Immunogen

Recombinant human NR2F6 protein expressed in E. coli

Species Reactivity:

  • Human

Negative Species:

Applications:

  • Flow Cytometry
  • Western Blotting
    Positive control: HEK293T/17/NR2F6/Ha-tag transfectants
    Negative control: HEK293T/17 cells
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

References

  • Unpublished.
  • For research use only. Not for drug, diagnostic or other use.

    Example Data

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