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Mouse Monoclonal to TFG

TFG-03 (IgG2b)

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  11-709-C025 purified 0.025 mg yes choose region PDF datasheetHTML datasheet buy
  11-709-C100 purified 0.1 mg yes choose region PDF datasheetHTML datasheet buy
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Background

TFG (TRK-fused gene protein) is a regulatory protein with not fully understood function. Its defects are associated with various carcinomas, such as e.g. melanoma, thyroid papillary carcinoma, or glioma. TFG structure (multiple protein interaction motifs) indicated it can be an adaptor protein. It has been demonstrated TFG interacts with proteins modulating the NFkappaB pathway (TANK and NEMO). TNG enhances the effect of TNFalpha, TANK, TRAF2 and TRAF6 in inducing NFkappaB activity.

Specificity

The mouse monoclonal antibody TFG-03 recognizes TFG, an approximately 50 kDa protein with regulatory functions.

Regulatory Status

Immunogen

Human recombinant protein Trx-his-NTFG

Species Reactivity:

  • Human

Negative Species:

Applications:

  • Immunoprecipitation
  • Western Blotting
  • Immunocytochemistry
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

General references

  • *Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S: Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Oncogene. 2003 May 22;22(21):3307-18. [Abstract]
  • *Miranda C, Roccato E, Raho G, Pagliardini S, Pierotti MA, Greco A: The TFG protein, involved in oncogenic rearrangements, interacts with TANK and NEMO, two proteins involved in the NF-kappaB pathway. J Cell Physiol. 2006 Jul;208(1):154-60. [Abstract]
  • For research use only. Not for drug, diagnostic or other use.

    Example Data

    TFG-03 WB


    Fig. 1. Western blotting analysis of TFG in Jurkat cell lysate using anti-TFG (TFG-03) purified.

    Unless indicated otherwise, all products are For Research Use Only and not for diagnostic or therapeutic use. Not for resale or transfer either as a stand-alone product or as a component of another product without written consent of EXBIO. EXBIO will not be held responsible for patent infringement or other violations that may occur with the use of our products. All orders are accepted subject to EXBIO´s term and conditions which are available at www.exbio.cz.
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