Mouse Monoclonal to TFG
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(TRK-fused gene protein) is a regulatory protein with not fully understood function. Its defects are associated with various carcinomas, such as e.g. melanoma, thyroid papillary carcinoma, or glioma. TFG structure (multiple protein interaction motifs) indicated it can be an adaptor protein. It has been demonstrated TFG interacts with proteins modulating the NFkappaB pathway (TANK and NEMO). TNG enhances the effect of TNFalpha, TANK, TRAF2 and TRAF6 in inducing NFkappaB activity.
The mouse monoclonal antibody TFG-03 recognizes TFG, an approximately 50 kDa protein with regulatory functions.
Human recombinant protein Trx-his-NTFG
- Western Blotting
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.
*Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S: Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Oncogene. 2003 May 22;22(21):3307-18. [Abstract]
*Miranda C, Roccato E, Raho G, Pagliardini S, Pierotti MA, Greco A: The TFG protein, involved in oncogenic rearrangements, interacts with TANK and NEMO, two proteins involved in the NF-kappaB pathway. J Cell Physiol. 2006 Jul;208(1):154-60. [Abstract]
For research use only. Not for drug, diagnostic or other use.
Western blotting analysis of TFG in Jurkat cell lysate using anti-TFG (TFG-03