System Certification ISO 9001:2000
Exbio Antibodies CZ / SK eShop
by categories | a-z list | Application type: Flow Cytometry | Immunohistochemistry | Functional Studies

Mouse Monoclonal to FOLR2

EM-35 (IgG1)

Technical Information Request    Inquiry for Bulk Prices

Product No. Form Quantity Stock Price Datasheet Shop
  11-696-C025 purified 0.025 mg yes choose region PDF datasheetHTML datasheet buy
  11-696-C100 purified 0.1 mg yes choose region PDF datasheetHTML datasheet buy
  1P-696-C025 PE 0.025 mg yes choose region PDF datasheetHTML datasheet buy
  1P-696-C100 PE 0.1 mg yes choose region PDF datasheetHTML datasheet buy
- In stock! Ready for immediate despatch - Manufacture on order


FOLR2 (folate receptor beta) is a cell surface protein that was originally thought to be specific for placenta, but it can be also expressed in other tissues, including hematopoietic cells. Its expression is increased in malignant tissues. FOLR2 may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. FOLR2 is a marker for macrophages generated in the presence of M-CSF (M2), including M2-like tumor-associated macrophages, which exert potent immunosuppressive functions within the tumor environment, but not GM-CSF (M1), and whose expression correlates with increased folate uptake ability.


The mouse monoclonal antibody EM-35 recognizes FOLR2, a 30-40 kDa cell surface protein serving as a receptor for folic acid.

Regulatory Status


BW5147alpha,beta- cells

Species Reactivity:

  • Human

Negative Species:

  • Mouse


  • Flow Cytometry
  • Immunoprecipitation
  • Western Blotting
    Application note:non-reducing conditions
  • Immunocytochemistry
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

Product Specific References

  • *Machacek C, Supper V, Leksa V, Mitulovic G, Spittler A, Drbal K, Suchanek M, Ohradanova-Repic A, Stockinger H: Folate Receptor β Regulates Integrin CD11b/CD18 Adhesion of a Macrophage Subset to Collagen. J Immunol. 2016 Sep 15;197(6):2229-38. [Abstract] [Full Text]
  • *Ohradanova-Repic A, Machacek C, Charvet C, Lager F, Le Roux D, Platzer R, Leksa V, Mitulovic G, Burkard TR, Zlabinger GJ, Fischer MB, Feuillet V, Renault G, Blüml S, Benko M, Suchanek M, Huppa JB, Matsuyama T, Cavaco-Paulo A, Bismuth G, Stockinger H: Extracellular Purine Metabolism Is the Switchboard of Immunosuppressive Macrophages and a Novel Target to Treat Diseases With Macrophage Imbalances. Front Immunol. 2018 Apr 27;9:852. [Abstract] [Full Text]
  • For research use only. Not for drug, diagnostic or other use.

    Example Data

    EM-35 PE

    Fig. 1. Surface staining of FOLR2 transfectants (red) with anti-human FOLR2 (EM-35) PE; compared with blank (blue).

    EM-35 WB

    Fig. 2. Western blotting analysis of FOLR2 in THP1 cells (A) and FOLR2-transfected THP1 cells (B) using anti-FOLR2 (EM-35) purified.

    Unless indicated otherwise, all products are For Research Use Only and not for diagnostic or therapeutic use. Not for resale or transfer either as a stand-alone product or as a component of another product without written consent of EXBIO. EXBIO will not be held responsible for patent infringement or other violations that may occur with the use of our products. All orders are accepted subject to EXBIO´s term and conditions which are available at
    © 2003 EXBIO. All rights reserved.
    terms and conditions | privacy policy