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Mouse Monoclonal to OPAL1

OPAL1-01 (IgG2a)

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Background

OPAL1 (outcome predictor in acute leukemia 1) is an almost uncharacterized transmembrane adaptor protein expressed mainly by megacaryocytes and platelets. Its expression is enhanced on TEL/AML leukemic cells. The function of OPAL1 is unknown, although the presence of a cytochrome c-like heme-binding site and a transmembrane domain suggested OPAL1 may be involved in the mitochondrial electron transport chain. Its originally reported prognostic impact appears to be treatment dependent.

Specificity

The mouse monoclonal antibody OPAL1-01 recognizes OPAL1 (outcome predictor in acute leukemia 1), a transmembrane adaptor protein expressed mainly by megacaryocytes and platelets.

Regulatory Status

Immunogen

Recombinant fragment of human OPAL1 (amino acids 152-342)

Species Reactivity:

  • Human

Negative Species:

Applications:

  • Flow Cytometry
    Application note:intracellular staining
  • Western Blotting
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

General references

  • *Holleman A, den Boer ML, Cheok MH, Kazemier KM, Pei D, Downing JR, Janka-Schaub GE, G÷bel U, Graubner UB, Pui CH, Evans WE, Pieters R: Expression of the outcome predictor in acute leukemia 1 (OPAL1) gene is not an independent prognostic factor in patients treated according to COALL or St Jude protocols. Blood. 2006 Sep 15;108(6):1984-90. [Abstract] [Full Text]
  • For research use only. Not for drug, diagnostic or other use.

    Example Data




    OPAL1-01 WB
    Fig. 1.


    Fig. 1. Western blotting analysis of OPAL1 in OPAL1-transfected HEK293 cells using mouse monoclonal antibody OPAL1-01.


    OPAL1-01 FC
    Fig. 2.


    Fig. 2. Flow cytometry analysis of OPAL-transfected HEK293 cells using mouse monoclonal antibody OPAL1-01.


    OPAL1-01 PE


    Fig. 3. Flow cytometry analysis of OPAL1 in human peripheral blood + lyophilized SP2 cells using mouse monoclonal antibody anti-OPAL1 (OPAL1-01) PE.



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