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Mouse Monoclonal to CD103 / Integrin alpha E

Ber-ACT8 (IgG1)

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Product No. Form Quantity Stock Price Datasheet Shop
  11-670-C025 purified 0.025 mg yes choose region PDF datasheetHTML datasheet buy
  11-670-C100 purified 0.1 mg yes choose region PDF datasheetHTML datasheet buy
  1F-670-T025 FITC 25 tests yes choose region PDF datasheetHTML datasheet buy
  1F-670-T100 FITC 100 tests yes choose region PDF datasheetHTML datasheet buy
  1P-670-T025 PE 25 tests yes choose region PDF datasheetHTML datasheet buy
  1P-670-T100 PE 100 tests yes choose region PDF datasheetHTML datasheet buy
  1A-670-T025 APC 25 tests yes choose region PDF datasheetHTML datasheet buy
  1A-670-T100 APC 100 tests yes choose region PDF datasheetHTML datasheet buy
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Background

CD103 / Integrin alphaE is an integrin subunit that is expressed on intraepithelial lymphocytes, epithelial dendritic cells, lamina propria-derived dendritic cells, a subpopulation of lamina propria T cells, a small subset of peripheral lymphocytes, namely T reg cells, and on activated and TGF-beta stimulated lymphocytes. CD103 is in mature form cleaved into two disulfide-linked chains (C-terminal 150 kDa chain and N-terminal 25 kDa chain). It heterodimerizes with integrin beta7 subunit to form alphaE/beta7 integrin (mucosal lymphocyte 1 antigen), which through binding E-cadherin mediates homing of lymphocytes to the intestinal epithelium, and, in addition to the role in adhesion, may serve as an accessory molecule for intraepithelial lymphocyte activation.

Specificity

The mouse monoclonal antibody Ber-ACT8 recognizes CD103 (alpha E integrin), a type I transmembrane glycoprotein primarily found on intestinal intraepithelial lymphocytes.
HLDA V; WS Code A067

Regulatory Status

Immunogen

HTLV-1 induced human T cell line MAPS16

Species Reactivity:

  • Human
  • Non-Human Primates

Negative Species:

Applications:

  • Flow Cytometry
  • Immunoprecipitation
  • Western Blotting
  • Immunohistochemistry (frozen sections)
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

Product Specific References

  • *Jaensson E, Uronen-Hansson H, Pabst O, Eksteen B, Tian J, Coombes JL, Berg PL, Davidsson T, Powrie F, Johansson-Lindbom B, Agace WW: Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans. J Exp Med. 2008 Sep 1;205(9):2139-49. [Abstract] [Full Text]
  • *Zhang L, Bertucci AM, Ramsey-Goldman R, Burt RK, Datta SK: Regulatory T cell (Treg) subsets return in patients with refractory lupus following stem cell transplantation, and TGF-beta-producing CD8+ Treg cells are associated with immunological remission of lupus. J Immunol. 2009 Nov 15;183(10):6346-58. [Abstract] [Full Text]
  • *Cardoso CR, Garlet GP, Moreira AP, Júnior WM, Rossi MA, Silva JS: Characterization of CD4+CD25+ natural regulatory T cells in the inflammatory infiltrate of human chronic periodontitis. J Leukoc Biol. 2008 Jul;84(1):311-8. [Abstract] [Full Text]
  • *French JJ, Cresswell J, Wong WK, Seymour K, Charnley RM, Kirby JA: T cell adhesion and cytolysis of pancreatic cancer cells: a role for E-cadherin in immunotherapy? Br J Cancer. 2002 Oct 21;87(9):1034-41. [Abstract] [Full Text]
  • *Brandes M, Willimann K, Lang AB, Nam KH, Jin C, Brenner MB, Morita CT, Moser B: Flexible migration program regulates gamma delta T-cell involvement in humoral immunity. Blood. 2003 Nov 15;102(10):3693-701. [Abstract] [Full Text]
  • *Kost CB, Holden JT, Mann KP: Marginal zone B-cell lymphoma: a retrospective immunophenotypic analysis. Cytometry B Clin Cytom. 2008 Sep;74(5):282-6. [Abstract] [Full Text]
  • *Kost CB, Holden JT, Mann KP: Marginal zone B-cell lymphoma: a retrospective immunophenotypic analysis. Cytometry B Clin Cytom. 2008 Sep;74(5):282-6. [Abstract] [Full Text]
  • *Sigmundsdottir H, Johnston A, Gudjonsson JE, Bjarnason B, Valdimarsson H: Methotrexate markedly reduces the expression of vascular E-selectin, cutaneous lymphocyte-associated antigen and the numbers of mononuclear leucocytes in psoriatic skin. Exp Dermatol. 2004 Jul;13(7):426-34. [Abstract]
  • *León F, Roy G: Isolation of human small bowel intraepithelial lymphocytes by annexin V-coated magnetic beads. Lab Invest. 2004 Jun;84(6):804-9. [Abstract]
  • *Poles MA, Barsoum S, Yu W, Yu J, Sun P, Daly J, He T, Mehandru S, Talal A, Markowitz M, Hurley A, Ho D, Zhang L: Human immunodeficiency virus type 1 induces persistent changes in mucosal and blood gammadelta T cells despite suppressive therapy. J Virol. 2003 Oct;77(19):10456-67. [Abstract] [Full Text]
  • *And other.
  • For research use only. Not for drug, diagnostic or other use.

    Example Data

    Ber-ACT8 APC


    Fig. 1. Surface staining of CD103 on human peripheral blood cells with anti-CD103 (Ber-ACT8) APC.


    1F-670


    Fig. 2. Surface staining of CD103 on PHA-activated PBMC with anti-CD103 (Ber-ACT8) FITC.


    Ber-ACT8 PE


    Fig. 3. Surface staining of CD103 on PHA-activated PBMC with anti-CD103 (Ber-ACT8) PE.

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