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Mouse Monoclonal to CD209

UW60.1 (IgG1)

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  11-640-C025 purified 0.025 mg yes choose region PDF datasheetHTML datasheet buy
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  1P-640-T025 PE 25 tests yes choose region PDF datasheetHTML datasheet buy
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  1A-640-T025 APC 25 tests yes choose region PDF datasheetHTML datasheet buy
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  A6-640-T100 Alexa Fluor® 647 100 tests yes choose region PDF datasheetHTML datasheet buy
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Background

CD209, also known as DC-SIGN (dendritic cell-specific ICAM-3-grabbing nonintegrin) is a transmembrane receptor expressed on the surface of dendritic cells and macrophages, which recognizes numerous pathogens ranging from parasites to viruses. Its N-terminal domain is transmembrane, whereas a tandem-repeat neck domain and the C terminal C-type lectin carbohydrate recognition domain have dual function as a pathogen recognition receptor and a cell adhesion receptor. The neck region is responsible for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. A ligand of CD209 is also CD50 (ICAM-3).

Specificity

The mouse monoclonal antibody UW60.1 recognizes human CD209 (DC-SIGN), a 44 kDa transmembrane receptor expressed on the surface of dendritic cells and macrophages.

Regulatory Status

Immunogen

CD209-His-tagged fusion protein

Species Reactivity:

  • Human

Negative Species:

Applications:

  • Flow Cytometry
  • Immunohistochemistry
  • Immunocytochemistry
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

General references

  • *Khoo US, Chan KY, Chan VS, Lin CL: DC-SIGN and L-SIGN: the SIGNs for infection. J Mol Med. 2008 Aug;86(8):861-74. [Abstract]
  • *van Kooyk Y, Geijtenbeek TB: A novel adhesion pathway that regulates dendritic cell trafficking and T cell interactions. Immunol Rev. 2002 Aug;186:47-56. [Abstract]
  • *Geijtenbeek TB, Engering A, Van Kooyk Y: DC-SIGN, a C-type lectin on dendritic cells that unveils many aspects of dendritic cell biology. J Leukoc Biol. 2002 Jun;71(6):921-31. [Abstract] [Full Text]
  • Product Specific References

  • *Ryan EJ, Marshall AJ, Magaletti D, Floyd H, Draves KE, Olson NE, Clark EA: Dendritic cell-associated lectin-1: a novel dendritic cell-associated, C-type lectin-like molecule enhances T cell secretion of IL-4. J Immunol. 2002 Nov 15;169(10):5638-48. [Abstract] [Full Text]
  • For research use only. Not for drug, diagnostic or other use.

    Example Data

    UW60-1 APC


    Fig. 1. Surface staining of human monocytes-derived dendritic cells with anti-human CD209 (UW60.1) APC.



    UW60-1 PE


    Fig. 2. Surface staining of human monocytes-derived dendritic cells with anti-human CD209 (UW60.1) PE.



    UW60-1 AF647


    Fig. 3. Surface staining of human monocytes-derived dendritic cells with anti-human CD209 (UW60.1) Alexa Fluor® 647.

    Unless indicated otherwise, all products are For Research Use Only and not for diagnostic or therapeutic use. Not for resale or transfer either as a stand-alone product or as a component of another product without written consent of EXBIO. EXBIO will not be held responsible for patent infringement or other violations that may occur with the use of our products. All orders are accepted subject to EXBIO´s term and conditions which are available at www.exbio.cz.
    Alexa Fluor®, Pacific Blue™ and Pacific Orange™ are registred trademarks of Molecular Probes Inc., Eugene, OR, USA. (licence label)
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