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Mouse Monoclonal to Kappa light chains

TB28-2 (IgG1)

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Background

Immunoglobulin classes share the same basic four polypeptide chain structure of two heavy chains (five heavy chains types) and two light chains (kappa, lambda; both having a molecular weight of 22.5kDa). Kappa and lambda consist of a variable region and a constant region and can easily be differentiated by the antigenic properties of the constant region. The ratio of kappa to lambda is 70:30.

Specificity

The antibody TB28-2 recognizes human Ig kappa light chains of both secreted and cell surface immunoglobulin. It detects also free kappa light chains.

Regulatory Status

Immunogen

Human IgG-kappa myeloma protein

Species Reactivity:

  • Human

Negative Species:

Applications:

  • Flow Cytometry
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

Product Specific References

  • *Kiyotaki M, Cooper MD, Bertoli LF, Kearney JF, Kubagawa H: Monoclonal anti-Id antibodies react with varying proportions of human B lineage cells. J Immunol. 1987 Jun 15;138(12):4150-8. [Abstract]
  • *Nakamura T, Kubagawa H, Cooper MD: Heterogeneity of immunoglobulin-associated molecules on human B cells identified by monoclonal antibodies. Proc Natl Acad Sci U S A. 1992 Sep 15;89(18):8522-6. [Abstract] [Full Text]
  • *B÷ttcher S, Ritgen M, Buske S, Gesk S, Klapper W, Hoster E, Hiddemann W, Unterhalt M, Dreyling M, Siebert R, Kneba M, Pott C; EU MCL MRD Group: Minimal residual disease detection in mantle cell lymphoma: methods and significance of four-color flow cytometry compared to consensus IGH-polymerase chain reaction at initial staging and for follow-up examinations. Haematologica. 2008 Apr;93(4):551-9. [Abstract]
  • *Karandikar NJ, Aquino DB, McKenna RW, Kroft SH: Transient myeloproliferative disorder and acute myeloid leukemia in Down syndrome. An immunophenotypic analysis. Am J Clin Pathol. 2001 Aug;116(2):204-10. [Abstract] [Full Text]
  • *Jourdan M, Caraux A, De Vos J, Fiol G, Larroque M, Cognot C, Bret C, Duperray C, Hose D, Klein B: An in vitro model of differentiation of memory B cells into plasmablasts and plasma cells including detailed phenotypic and molecular characterization. Blood. 2009 Dec 10;114(25):5173-81. [Abstract] [Full Text]
  • For research use only. Not for drug, diagnostic or other use.

    Example Data

    TB28-2 APC


    Fig. 1. Surface staining of kappa light chains in human peripheral blood cells with anti-kappa light chains (TB28-2) APC.

    TB28-2 PE


    Fig. 2. Surface staining of kappa light chains in human peripheral blood cells with anti-kappa light chains (TB28-2) PE.


    TB28-2 APC-Cy7


    Fig. 3. Surface staining of kappa light chains in human peripheral blood cells with anti-kappa light chains (TB28-2) APC-CyTM7.


    TB28-2 Pacific Blue FC


    Fig. 4. Surface staining of kappa light chains in human peripheral blood cells with anti-kappa light chains (TB28-2) Pacific BlueTM.

    Unless indicated otherwise, all products are For Research Use Only and not for diagnostic or therapeutic use. Not for resale or transfer either as a stand-alone product or as a component of another product without written consent of EXBIO. EXBIO will not be held responsible for patent infringement or other violations that may occur with the use of our products. All orders are accepted subject to EXBIO┤s term and conditions which are available at www.exbio.cz.
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    Cy™ and CyDye™ are registered trademarks of GE Healthcare.
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