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Mouse Monoclonal to CD90

5E10 (IgG1)

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Product No. Form Quantity Stock Price Datasheet Shop
  10-652-C025 azide free 0.025 mg yes choose region PDF datasheetHTML datasheet buy
  10-652-C100 azide free 0.1 mg yes choose region PDF datasheetHTML datasheet buy
  1F-652-T025 FITC 25 tests yes choose region PDF datasheetHTML datasheet buy
  1F-652-T100 FITC 100 tests yes choose region PDF datasheetHTML datasheet buy
  1P-652-T025 PE 25 tests yes choose region PDF datasheetHTML datasheet buy
  1P-652-T100 PE 100 tests yes choose region PDF datasheetHTML datasheet buy
  1A-652-T025 APC 25 tests yes choose region PDF datasheetHTML datasheet buy
  1A-652-T100 APC 100 tests yes choose region PDF datasheetHTML datasheet buy
  T8-652-T025 PE-Cy™5 25 tests yes choose region PDF datasheetHTML datasheet buy
  T8-652-T100 PE-Cy™5 100 tests yes choose region PDF datasheetHTML datasheet buy
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Background

CD90 (Thy-1) is an 18-35 kDa GPI-anchored plasma membrane glycoprotein expressed in many cell types, such as in hematopoietic cells and neurons, connective tissues, various fibroblast and stromal cell lines, tumor endothelial cell lines and other. It is involved in T cell activation, cellular adhesion, proliferation and migration, neurite outgrowth, wound healing, apoptosis, and fibrosis. CD90 participates in multiple signaling cascades and its effects are tissue- and cell type-specific. It often functions as an important regulator of cell-cell and cell-matrix interactions.

Specificity

The mouse monoclonal antibody 5E10 recognizes CD90/Thy-1, a GPI-anchored cell surface glycoprotein expressed predominantly on thymocytes, hematopoietic stem cells and neurons.
HLDA V; WS Code M07, BP222
HLDA VI; WS Code BP28, E046

Regulatory Status

Immunogen

HEL erythroleukemia cells

Species Reactivity:

  • Human
  • Non-Human Primates
  • Porcine
  • Equine (Horse)

Negative Species:

Applications:

  • Flow Cytometry
  • Immunoprecipitation
  • Western Blotting
  • Immunohistochemistry (frozen sections)
  • Immunocytochemistry
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

Product Specific References

  • *Ito T, Inaba M, Inaba K, Toki J, Sogo S, Iguchi T, Adachi Y, Yamaguchi K, Amakawa R, Valladeau J, Saeland S, Fukuhara S, Ikehara S: A CD1a+/CD11c+ subset of human blood dendritic cells is a direct precursor of Langerhans cells. J Immunol. 1999 Aug 1;163(3):1409-19. [Abstract] [Full Text]
  • *St Louis DC, Woodcock JB, Franzoso G, Blair PJ, Carlson LM, Murillo M, Wells MR, Williams AJ, Smoot DS, Kaushal S, Grimes JL, Harlan DM, Chute JP, June CH, Siebenlist U, Lee KP: Evidence for distinct intracellular signaling pathways in CD34+ progenitor to dendritic cell differentiation from a human cell line model. J Immunol. 1999 Mar 15;162(6):3237-48. [Abstract] [Full Text]
  • *Chin-Yee IH, Keeney M, Stewart AK, Belch A, Bence-Buckler I, Couban S, Howson-Jan K, Rubinger M, Stewart D, Sutherland R, Paragamian V, Bhatia M, Foley R: Optimising parameters for peripheral blood leukapheresis after r-metHuG-CSF (filgrastim) and r-metHuSCF (ancestim) in patients with multiple myeloma: a temporal analysis of CD34(+) absolute counts and subsets. Bone Marrow Transplant. 2002 Dec;30(12):851-60. [Abstract] [Full Text]
  • *Carlsten M, Björkström NK, Norell H, Bryceson Y, van Hall T, Baumann BC, Hanson M, Schedvins K, Kiessling R, Ljunggren HG, Malmberg KJ: DNAX accessory molecule-1 mediated recognition of freshly isolated ovarian carcinoma by resting natural killer cells. Cancer Res. 2007 Feb 1;67(3):1317-25. [Abstract] [Full Text]
  • *Kroeze KL, Jurgens WJ, Doulabi BZ, van Milligen FJ, Scheper RJ, Gibbs S: Chemokine-mediated migration of skin-derived stem cells: predominant role for CCL5/RANTES. J Invest Dermatol. 2009 Jun;129(6):1569-81. [Abstract] [Full Text]
  • *Hoppstädter J, Diesel B, Zarbock R, Breinig T, Monz D, Koch M, Meyerhans A, Gortner L, Lehr CM, Huwer H, Kiemer AK: Differential cell reaction upon Toll-like receptor 4 and 9 activation in human alveolar and lung interstitial macrophages. Respir Res. 2010 Sep 15;11:124. [Abstract] [Full Text]
  • *Signal-regulatory protein alpha (SIRPalpha) but not SIRPbeta is involved in T-cell activation, binds to CD47 with high affinity, and is expressed on immature CD34(+)CD38(-) hematopoietic cells. Blood. 2001 May 1;97(9):2741-9. [Abstract] [Full Text]
  • *And many other.
  • For research use only. Not for drug, diagnostic or other use.

    Example Data

    5E10 PE-Cy5


    Fig. 1. Surface staining of CD90 in Jurkat cells with anti-CD90 (5E10) PE-CyTM5.


    5E10 FITC


    Fig. 2. Surface staining of CD90 in Jurkat cells with anti-CD90 (5E10) FITC.


    5E10 APC


    Fig. 3. Surface staining of CD90 in Jurkat cells with anti-CD90 (5E10) APC.


    5E10 PE


    Fig. 4. Surface staining of CD90 in Jurkat cells with anti-CD90 (5E10) PE.

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