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Mouse Monoclonal to CD84

CD84.1.21 (IgG2a)

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Product No. Form Quantity Stock Price Datasheet Shop
  11-661-C025 purified 0.025 mg yes choose region PDF datasheetHTML datasheet buy
  11-661-C100 purified 0.1 mg yes choose region PDF datasheetHTML datasheet buy
  12-661-C100 low endotoxin 0.1 mg yes choose region PDF datasheetHTML datasheet buy
  1F-661-T025 FITC 25 tests yes choose region PDF datasheetHTML datasheet buy
  1F-661-T100 FITC 100 tests yes choose region PDF datasheetHTML datasheet buy
  1P-661-T025 PE 25 tests yes choose region PDF datasheetHTML datasheet buy
  1P-661-T100 PE 100 tests yes choose region PDF datasheetHTML datasheet buy
  1A-661-T025 APC 25 tests yes choose region PDF datasheetHTML datasheet buy
  1A-661-T100 APC 100 tests yes choose region PDF datasheetHTML datasheet buy
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Background

CD84 is a highly glycosylated homophilic receptor of SLAM family. It is expressed on platelets and various types of leukocytes, especially following their activation. Ligation of CD84 leads to its phosphorylation on tyrosine residues within the cytoplasmic tail. These docking sites are recognized by downstream signaling molecules, such as phosphatase SHP-2 and adaptor protein SAP/SH2D1A. The function of CD84 has not been fully elucidated yet. Although predominantly activating receptor, its modulating activity was also demonstrated.

Specificity

The mouse monoclonal antibody CD84.1.21 recognizes CD84, a single chain cell surface glycoprotein of 64-82 kDa, predominantly expressed B cells, monocytes, platelets and some T cells.

Regulatory Status

Immunogen

CD84-transfected 300.19 cell line

Species Reactivity:

  • Human

Negative Species:

Applications:

  • Flow Cytometry
  • Immunoprecipitation
  • Functional Application
    Enhancement of CD3-induced IFN-gamma production
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

Product Specific References

  • *Sayós J, Martín M, Chen A, Simarro M, Howie D, Morra M, Engel P, Terhorst C: Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP. Blood. 2001 Jun 15;97(12):3867-74. [Abstract] [Full Text]
  • *Martin M, Romero X, de la Fuente MA, Tovar V, Zapater N, Esplugues E, Pizcueta P, Bosch J, Engel P: CD84 functions as a homophilic adhesion molecule and enhances IFN-gamma secretion: adhesion is mediated by Ig-like domain 1. J Immunol. 2001 Oct 1;167(7):3668-76. [Abstract] [Full Text]
  • *Morra M, Lu J, Poy F, Martin M, Sayos J, Calpe S, Gullo C, Howie D, Rietdijk S, Thompson A, Coyle AJ, Denny C, Yaffe MB, Engel P, Eck MJ, Terhorst C: Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells. EMBO J. 2001 Nov 1;20(21):5840-52. [Abstract] [Full Text]
  • *Morra M, Simarro-Grande M, Martin M, Chen AS, Lanyi A, Silander O, Calpe S, Davis J, Pawson T, Eck MJ, Sumegi J, Engel P, Li SC, Terhorst C: Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients. J Biol Chem. 2001 Sep 28;276(39):36809-16. [Abstract] [Full Text]
  • *Romero X, Zapater N, Calvo M, Kalko SG, de la Fuente MA, Tovar V, Ockeloen C, Pizcueta P, Engel P: CD229 (Ly9) lymphocyte cell surface receptor interacts homophilically through its N-terminal domain and relocalizes to the immunological synapse. J Immunol. 2005 Jun 1;174(11):7033-42. [Abstract] [Full Text]
  • For research use only. Not for drug, diagnostic or other use.

    Example Data

    CD84-1-21 FITC


    Fig. 1. Surface staining of CD84 in human peripheral blood with anti-CD84 (CD84.1.21) FITC.


    CD84-1-21 PE


    Fig. 2. Surface staining of CD84 in human peripheral blood with anti-CD84 (CD84.1.21) PE.


    CD84-1-21 APC


    Fig. 3. Surface staining of CD84 in human peripheral blood with anti-CD84 (CD84.1.21) APC.

    Unless indicated otherwise, all products are For Research Use Only and not for diagnostic or therapeutic use. Not for resale or transfer either as a stand-alone product or as a component of another product without written consent of EXBIO. EXBIO will not be held responsible for patent infringement or other violations that may occur with the use of our products. All orders are accepted subject to EXBIO´s term and conditions which are available at www.exbio.cz.
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