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Mouse Monoclonal to CD17 / Lactosylceramide

MEM-68 (IgM)

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Background

CD17, lactosylceramide, is an ubiquitous glycosphingolipid with uncharged disaccharide headgroup, highly enriched in lipid raft-derived structures. Besides playing a pivotal role in the biosynthesis of complex glycosphingilipids, lactosylceramide is involved in cell-cell and cell-matrix interactions and in signaling events linked to cell differentiation, development, apoptosis and oncogenesis. Lactosylceramide regulates integrin functions and production of nitric oxide. Its expression defines successive stages in the maturation of myeloid cells.

Specificity

The mouse monoclonal antibody MEM-68 recognizes CD17, a membrane lipid moiety lactosylceramide expressed on granulocytes, monocytes and platelets.

Regulatory Status

Immunogen

Pre-B cell line NALM-6

Species Reactivity:

  • Human

Negative Species:

Applications:

  • Flow Cytometry
    Recommended dilution:2 μg/ml
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

General references

  • *Bhunia AK, Arai T, Bulkley G, Chatterjee S: Lactosylceramide mediates tumor necrosis factor-alpha-induced intercellular adhesion molecule-1 (ICAM-1) expression and the adhesion of neutrophil in human umbilical vein endothelial cells. J Biol Chem. 1998 Dec 18;273(51):34349-57. [Abstract] [Full Text]
  • *Spychalska J, Smoleńska-Sym G, Zdebska E, Woźniak J, Kościelak J: Quantitative analysis of LacCer/CDw17 in human myelogenous leukaemic cells. Cell Mol Biol Lett. 2003;8(4):911-7. [Abstract]
  • *Pannu R, Singh AK, Singh I: A novel role of lactosylceramide in the regulation of tumor necrosis factor alpha-mediated proliferation of rat primary astrocytes. Implications for astrogliosis following neurotrauma. J Biol Chem. 2005 Apr 8;280(14):13742-51. [Abstract] [Full Text]
  • *Sharma DK, Brown JC, Cheng Z, Holicky EL, Marks DL, Pagano RE: The glycosphingolipid, lactosylceramide, regulates beta1-integrin clustering and endocytosis. Cancer Res. 2005 Sep 15;65(18):8233-41. [Abstract] [Full Text]
  • *Zhai X, Li XM, Momsen MM, Brockman HL, Brown RE: Lactosylceramide: lateral interactions with cholesterol. Biophys J. 2006 Oct 1;91(7):2490-500. [Abstract] [Full Text]
  • For research use only. Not for drug, diagnostic or other use.

    Example Data

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