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Mouse Monoclonal to CD361

MEM-216 (IgG1)

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Background

CD361, also known as EVI2B (Ecotropic Viral Integration site 2B) or EVDB, is a poorly characterized type I transmembrane protein, expressed from one of three genes embedded in intron 27b of the neurofibromatosis type 1 (NF1) gene. The DNA strand that is transcribed to produce CD361 is the complementary one to the strand encoding NF1. Murine homolog to human CD361 is associated with ecotropic viral insertions, which have been implicated in the expression of murine myeloid leukemias. CD361 has been also reported to be involved in melanocyte and keratinocyte differentiation. However, it is expressed mainly in peripheral blood and bone marrow.

Specificity

The mouse monoclonal antibody MEM-216 recognizes CD361 / EVI2B, almost uncharacterized type I transmembrane protein with broad leukocyte expression, mostly in myeloid and B cells.
HLDA IX.; WS Code 263

Regulatory Status

Immunogen

Raji cells

Species Reactivity:

  • Human

Negative Species:

Applications:

  • Flow Cytometry
    Positive control:Raji, Daudi, HL-60 cells, peripheral blood lymphcocytes (strongly positive on CD19+ cells)
    Negative control:Jurkat, U-937 cells
  • Immunoprecipitation
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

General references

  • *Viskochil D, Cawthon R, O'Connell P, Xu GF, Stevens J, Culver M, Carey J, White R: The gene encoding the oligodendrocyte-myelin glycoprotein is embedded within the neurofibromatosis type 1 gene. Mol Cell Biol. 1991 Feb;11(2):906-12. [Abstract] [Full Text]
  • *Kaufmann D, Gruener S, Braun F, Stark M, Griesser J, Hoffmeyer S, Bartelt B: EVI2B, a gene lying in an intron of the neurofibromatosis type 1 (NF1) gene, is as the NF1 gene involved in differentiation of melanocytes and keratinocytes and is overexpressed in cells derived from NF1 neurofibromas. DNA Cell Biol. 1999 May;18(5):345-56. [Abstract]
  • For research use only. Not for drug, diagnostic or other use.

    Example Data

    MEM-216
    Fig. 1.


    Fig. 1. Flow cytometry analysis of CD19+ peripheral blood leukocytes using anti-CD361 antibody (MEM-216).


    MEM-216 PE


    Fig. 2. Surface staining of human peripheral blood using anti-CD361 antibody (MEM-216) PE. 

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