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Mouse Monoclonal to CD173

MEM-198 (IgM)

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Background

CD173 (blood group antigen H2) is a fucosylated saccharide (Fuc-alpha-1-2-Gal-beta-1-4-GlcNAc-beta) generated by beta-D-galactoside 2-alpha-L-fucosyltransferase (FUT1). CD173 belongs to markers of early hematopoiesis; it is expressed mainly on CD34-positive hematopoietic progenitor cells. CD173 is a precursor structure of CD174 (Lewis Y) and is also structurally related to CD15 (Lewis X). On endothelial cells CD173 and CD174 are concentrated on pseudopodial extensions responsible for initial contacts between endothelial cells.

Specificity

The antibody MEM-198 reacts with CD173 (H2), a saccharide antigen expressed mainly during early hematopoiesis; it is also expressed on endothelial cells.
HLDA 7, WS code: 70284

Regulatory Status

Immunogen

Human thrombocytes

Species Reactivity:

  • Human

Negative Species:

Applications:

  • Flow Cytometry
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

General references

  • *Cao Y, Merling A, Karsten U, Schwartz-Albiez R: The fucosylated histo-blood group antigens H type 2 (blood group O, CD173) and Lewis Y (CD174) are expressed on CD34+ hematopoietic progenitors but absent on mature lymphocytes. Glycobiology. 2001 Aug;11(8):677-83. [Abstract] [Full Text]
  • *Moehler TM, Sauer S, Witzel M, Andrulis M, Garcia-Vallejo JJ, Grobholz R, Willhauck-Fleckenstein M, Greiner A, Goldschmidt H, Schwartz-Albiez R: Involvement of alpha 1-2-fucosyltransferase I (FUT1) and surface-expressed Lewis(y) (CD174) in first endothelial cell-cell contacts during angiogenesis. J Cell Physiol. 2008 Apr;215(1):27-36. [Abstract]
  • Product Specific References

  • *Leukocyte Typing VII., Mason D.Y. et al. (Eds.), Oxford University Press (2002).
  • For research use only. Not for drug, diagnostic or other use.

    Example Data

    MEM-198 TKS FC



    Fig. 1.
    Surface staining of human peripheral blood using anti-human CD173 (clone MEM-198), culture supernatant / GAM-APC.

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