Rabbit Polyclonal to mGluR1b
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protein is an isoform of the metabotropic glutamate receptor 1 (mGluR1). The mGluR1, together with mGluR5 (both constituting group I of mGluRs), is coupled to the inositol phosphate/Ca[2+] signal transduction pathway, whereas the other five metabotropic glutamate receptors (mGluR2, mGluR3, mGluR4, mGluR6, mGluR7 ) are linked to the inhibition of the cAMP cascade. The highest level of mGluR1 mRNA expression is found in the cerebellar Purkinje cells. Three splicing variants have been described for mGluR1: mGluR1a (alpha), mGluR1b (beta), and mGluR1c. The mGluR1a and mGluR1b functionally differ e.g. in their internalisation responses or in ability to activate the Gs protein pathway, as the mGluR1b lacks a part of C terminus.
Entrez Gene (mouse): 10 A2
The rabbit polyclonal antibody recognizes C-terminus of metabotropic glutamate receptor 1 isoform mGluR1b. The mGluR1a isoform is not recognized.
KLH-coupled synthetic peptide derived from the last 19 amino acids of rat/human mGluR1b. Only 1 amino acid is different from the mouse last 19 amino acids of mGluR1b (V-->A).
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.
*Song JH, Park ES, Han SM, Han SR, Ahn DK, Youn DH: Signal transduction mechanisms underlying group I mGluR-mediated increase in frequency and amplitude of spontaneous EPSCs in the spinal trigeminal subnucleus
oralis of the rat. Mol Pain. 2009 Sep 2;5:50. [Abstract] [Full Text]
*Ciruela F, McIlhinney RA: Differential internalisation of mGluR1 splice variants in response to agonist and
phorbol esters in permanently transfected BHK cells. FEBS Lett. 1997 Nov 24;418(1-2):83-6. [Abstract]
*Tateyama M, Kubo Y: Coupling profile of the metabotropic glutamate receptor 1alpha is regulated by the C-terminal domain. Mol Cell Neurosci. 2007 Mar;34(3):445-52. [Abstract]
*Hong YH, Kim JY, Lee JH, Chae HG, Jang SS, Jeon JH, Kim CH, Kim J, Kim SJ: Agonist-induced internalization of mGluR1alpha is mediated by caveolin. J Neurochem. 2009 Oct;111(1):61-71. [Abstract]
*Marcaggi P, Mutoh H, Dimitrov D, Beato M, Knöpfel T: Optical measurement of mGluR1 conformational changes reveals fast activation, slow deactivation, and sensitization. Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11388-93. [Abstract] [Full Text]
For research use only. Not for drug, diagnostic or other use.
Western blotting analysis of HEK293-mGluR1b transfectants (1) and HEK293 cells transfected with pRK5 (2). The mGluR1b protein detected by anti-mGluR1b
rabbit polyclonal antibody.