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Mouse Monoclonal to CPNE7

CPNE7-01 (IgG)

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Product No. Form Quantity Stock Price Datasheet Shop
  11-542-C025 purified 0.025 mg yes choose region PDF datasheetHTML datasheet buy
  11-542-C100 purified 0.1 mg yes choose region PDF datasheetHTML datasheet buy
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Background

CPNE7 (copine VII) is a member of highly conserved copine family, which is composed of calcium-dependent membrane-binding proteins containing two N-terminal C domains and a C-terminal A domain (von Willenbrand domain). There is an evidence that copines (at least copine III) may represent a novel unconventional kinase family. CPNE7 is expressed mainly in brain, but also in duodenum, jejunum, thymus and testes.

Specificity

The antibody CPNE7-01 recognizes C terminus of human CPNE7, a calcium-binding cytoplasmic protein expressed mainly in brain.

Regulatory Status

Immunogen

Bacterially produced GST-fused C terminus of human CPNE7.

Species Reactivity:

  • Human
  • Other not determined

Negative Species:

Applications:

  • Western Blotting
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

General references

  • *Savino M, d'Apolito M, Centra M, van Beerendonk HM, Cleton-Jansen AM, Whitmore SA, Crawford J, Callen DF, Zelante L, Savoia A: Characterization of copine VII, a new member of the copine family, and its exclusion as a candidate in sporadic breast cancers with loss of heterozygosity at 16q24.3. Genomics. 1999 Oct 15;61(2):219-26. [Abstract]
  • *Caudell EG, Caudell JJ, Tang CH, Yu TK, Frederick MJ, Grimm EA: Characterization of human copine III as a phosphoprotein with associated kinase activity. Biochemistry. 2000 Oct 24;39(42):13034-43. [Abstract]
  • *Cowland JB, Carter D, Bjerregaard MD, Johnsen AH, Borregaard N, Lollike K: Tissue expression of copines and isolation of copines I and III from the cytosol of human neutrophils. J Leukoc Biol. 2003 Sep;74(3):379-88. [Abstract] [Full Text]
  • For research use only. Not for drug, diagnostic or other use.

    Example Data


    cpne
    Fig. 1.



    Fig. 1. Western Blotting analysis of CPNE7 using CPNE7-01 antibody in nuclear cell lysate (1) and cytoplasmic fraction (2) of HeLa cell extracts.

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