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Mouse Monoclonal to CRP

C2 (IgG1)

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  11-537-C100 purified 0.1 mg yes choose region PDF datasheetHTML datasheet buy
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Background

The C-reactive protein (CRP) is a cyclic pentameric pentraxin family acute phase protein compound of five identical noncovalently bound nonglycosylated subunits (each subunit 24 kDa; physiologic CRP molecule 117,5 kDa). CRP is produced by the liver and its plasma levels rise dramatically during inflammatory processes occuring in the body. CRP is an initiator of classical complement cascade, binds to several nuclear components (chromatin, histones, etc.) and is also believed to play an important role in innate immunity. Patients with elevated basal levels of CRP are at increased risk for hypertension and cardiovascular disease.

Specificity

The antibody C2 recognizes human CRP, an 117 kDa plasma acute phase protein; it recognizes the antigen both in the presence and in the absence (samples containing EDTA) of Ca2+.

Regulatory Status

Immunogen

Purified human CRP

Species Reactivity:

  • Human

Negative Species:

Applications:

  • ELISA
    The antibody C2 has been tested as the capture antibody in a sandwich ELISA for analysis of human C-Reactive Protein in combination with the antibody C6 (cat. no. 11-538-C100).
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

General references

  • *Meyer MH, Hartmann M, Krause HJ, Blankenstein G, Mueller-Chorus B, Oster J, Miethe P, Keusgen M: CRP determination based on a novel magnetic biosensor. Biosens Bioelectron. 2006 Jun 9. [Abstract]
  • *van der Harst P, Voors AA, Volbeda M, Buikema H, van Veldhuisen DJ, van Gilst WH: Usefulness of preoperative C-reactive protein and soluble intercellular adhesion molecule-1 level for predicting future cardiovascular events after coronary artery bypass grafting. Am J Cardiol. 2006 Jun 15;97(12):1697-701. [Abstract]
  • Product Specific References

  • *Meyer MH, Hartmann M, Krause HJ, Blankenstein G, Mueller-Chorus B, Oster J, Miethe P, Keusgen M: CRP determination based on a novel magnetic biosensor. Biosens Bioelectron. 2007 Jan 15;22(6):973-9. [Abstract]
  • For research use only. Not for drug, diagnostic or other use.

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  • Example Data

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