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Rabbit Polyclonal to CtBP1 / BARS

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  11-511-C100 purified 0.1 mg yes choose region PDF datasheetHTML datasheet buy
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Background

C-terminal binding protein 1 / brefeldin A (BFA)-dependent ADP-ribosylation substrate (CtBP1/BARS) is a highly conserved transcriptional corepressor, that plays a critical role in regulating gene expression patterns throughout development and in oncogenesis. CtBP regulates target gene transcription, in part, via recruitment of histone deacetylases involved in gene silencing and may act to coordonate histone modifications that regulate gene expression.

Specificity

The polyclonal antibody reacts with CtBP1, a 49 kDa transcriptional corepressor, that plays a critical role in regulating gene expression.

Regulatory Status

Immunogen

Bacterially expressed full-length human CtBP1

Species Reactivity:

  • Human
  • Mouse

Negative Species:

Applications:

  • Immunoprecipitation
  • Western Blotting
    Application note: Reducing conditions.
  • Immunocytochemistry
    Recommended dilution: 1 μg/ml
    Staining technique: acetone / methanol fixation
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

General references

  • *Lopez-Garcia J, Periyasamy M, Thomas RS, Christian M, Leao M, Jat P, Kindle KB, Heery DM, Parker MG, Buluwela L, Kamalati T, Ali S.: ZNF366 is an estrogen receptor corepressor that acts through CtBP and histone deacetylases. Nucleic Acids Res. 2006; 34(21):6126-36. [Abstract] [Full Text]
  • *Nadauld LD, Phelps R, Moore BC, Eisinger A, Sandoval IT, Chidester S, Peterson PW, Manos EJ, Sklow B, Burt RW, Jones D.A.: Adenomatous polyposis coli control of C-terminal binding protein-1 stability regulates expression of intestinal retinol dehydrogenases. J Biol Chem. 2006 Dec 8;281(49):37828-35. [Abstract] [Full Text]
  • *Valenta T, Lukas J, Korinek V.: HMG box transcription factor TCF-4's interaction with CtBP1 controls the expression of the Wnt target Axin2/Conductin in human embryonic kidney cells. Nucleic Acids Res. 2003 May 1;31(9):2369-80. [Abstract] [Full Text]
  • Product Specific References

  • *Valenta T, Lukas J, Doubravska L, Fafilek B, Korinek V.: HIC1 attenuates Wnt signaling by recruitment of TCF-4 and beta-catenin to the nuclear bodies. EMBO J. 2006 Jun 7;25(11):2326-37. [Abstract] [Full Text]
  • For research use only. Not for drug, diagnostic or other use.

    Example Data

    Unless indicated otherwise, all products are For Research Use Only and not for diagnostic or therapeutic use. Not for resale or transfer either as a stand-alone product or as a component of another product without written consent of EXBIO. EXBIO will not be held responsible for patent infringement or other violations that may occur with the use of our products. All orders are accepted subject to EXBIO´s term and conditions which are available at www.exbio.cz.
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