Mouse Monoclonal to CRP
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The C-reactive protein (CRP)
is a cyclic pentameric pentraxin family acute phase protein compound of five identical noncovalently bound nonglycosylated subunits (each subunit 24 kDa; physiologic CRP molecule 117,5 kDa). CRP is produced by the liver and its plasma levels rise dramatically during inflammatory processes occuring in the body. CRP is an initiator of classical complement cascade, binds to several nuclear components (chromatin, histones, etc.) and is also believed to play an important role in innate immunity. Patients with elevated basal levels of CRP are at increased risk for hypertension and cardiovascular disease.
The antibody C5 recognizes human CRP, an 117 kDa plasma acute phase protein; it recognizes antigen both in the presence and in the absence (samples containing EDTA) of Ca2+.
Purified human CRP
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.
*Meyer MH, Hartmann M, Krause HJ, Blankenstein G, Mueller-Chorus B, Oster J, Miethe P, Keusgen M.: CRP determination based on a novel magnetic biosensor. Biosens Bioelectron. 2006 Jun 9. [Abstract]
*van der Harst P, Voors AA, Volbeda M, Buikema H, van Veldhuisen DJ, van Gilst WH: Usefulness of preoperative C-reactive protein and soluble intercellular adhesion molecule-1 level for predicting future cardiovascular events after coronary artery bypass grafting. Am J Cardiol. 2006 Jun 15;97(12):1697-701. [Abstract]
Product Specific References
*Krämer PM, Kess M, Kremmer E, Schulte-Hostede S: Multi-parameter determination of TNFα, PCT and CRP for point-of-care testing. Analyst. 2011 Feb 21;136(4):692-5. [Abstract]
For research use only. Not for drug, diagnostic or other use.
Mouse IgG2a Isotype Control