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Rabbit Polyclonal to Mycobacterium tuberculosis antigen EsaT-6 (Rv3875)

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  11-491-C025 purified 0.025 mg yes choose region PDF datasheetHTML datasheet buy
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Background

The Mycobacterium tuberculosis antigen EsaT-6 (6 kDa early secretory antigen target EsxA ) causes induction of neutrophil necrosis. This protein acts as a leukocidin, which may facilitate bacterial avoidance of the antimicrobial action of the immune system.

Specificity

The rabbit polyclonal antibody to EsaT-6 recognizes the EsaT-6 (Rv3875) protein of Mycobacterium tuberculosis and Mycobacterium bovis.

Regulatory Status

Immunogen

EsaT-6 (Rv3875) of Mycobacterium tuberculosis

Species Reactivity:

  • Mycobacterium tuberculosis

Negative Species:

Applications:

  • Western Blotting
    Recommended dilution: 0.2 - 1 μg/ml
    Application note: Reducing conditions.
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

General references

  • *Arlehamn CS, Sidney J, Henderson R, Greenbaum JA, James EA, Moutaftsi M, Coler R, McKinney DM, Park D, Taplitz R, Kwok WW, Grey H, Peters B, Sette A: Dissecting mechanisms of immunodominance to the common tuberculosis antigens ESAT-6, CFP10, Rv2031c (hspX), Rv2654c (TB7.7), and Rv1038c (EsxJ). J Immunol. 2012 May 15;188(10):5020-31. [Abstract] [Full Text]
  • *Francis RJ, Butler RE, Stewart GR: Mycobacterium tuberculosis ESAT-6 is a leukocidin causing Ca2+ influx, necrosis and neutrophil extracellular trap formation. Cell Death Dis. 2014 Oct 16;5:e1474. [Abstract] [Full Text]
  • For research use only. Not for drug, diagnostic or other use.

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