System Certification ISO 9001:2000
Exbio Antibodies CZ / SK eShop
by categories | a-z list | Application type: Flow Cytometry | Immunohistochemistry | Functional Studies

Rabbit Polyclonal to NTAL / LAB

Technical Information Request    Inquiry for Bulk Prices

Product No. Form Quantity Stock Price Datasheet Shop
  11-486-C025 purified 0.025 mg yes choose region PDF datasheetHTML datasheet buy
  11-486-C100 purified 0.1 mg yes choose region PDF datasheetHTML datasheet buy
- In stock! Ready for immediate despatch - Manufacture on order


NTAL (Non-T cell activation linker), also known as LAB (Linker for activation of B cells), is a 30 kDa double-palmitoylated transmembrane adaptor protein expressed by B cells, NK cells, mast cells and macrophages. It is a negative regulator of early stages of BCR-dependent B cell signaling and serves as a negative regulator also in mast cells. However, in mast cells, NTAL also contributes to some activation processes, partially overlapping with LAT function.


The polyclonal antibody recognizes N-terminal cytoplasmic domain of mouse Non-T cell Activation Linker (NTAL), also known as LAB (linker of activated B cells), a 25 kDa transmembrane adaptor protein present in membrane microdomains (rafts) of B cells, NK cells and myeloid cells.

Regulatory Status


Recombinant N-terminal cytoplasmic domain (aa 124-203) of mouse NTAL.

Species Reactivity:

  • Mouse
  • Other species Not tested

Negative Species:

  • Human


  • Western Blotting
    Recommended dilution: 1 μg/ml
    Positive control: mouse spleen
    Sample preparation: Mix lysate with non-reducing SDS-PAGE sample buffer. Application note: Non-reducing conditions.
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

General references

  • *Horejsí V, Zhang W, Schraven B.: Transmembrane adaptor proteins: organizers of immunoreceptor signalling. Nat Rev Immunol. 2004 Aug;4(8):603-16. [Abstract]
  • *Yamasaki S, Ishikawa E, Sakuma M, Kanagawa O, Cheng AM, Malissen B, Saito T: LAT and NTAL mediate immunoglobulin E-induced sustained extracellular signal-regulated kinase activation critical for mast cell survival. Mol Cell Biol. 2007 Jun;27(12):4406-15. [Abstract] [Full Text]
  • Product Specific References

  • *Volná P, Lebduska P, Dráberová L, Símová S, Heneberg P, Boubelík M, Bugajev V, Malissen B, Wilson BS, Horejsí V, Malissen M, Dráber P: Negative regulation of mast cell signaling and function by the adaptor LAB/NTAL. J Exp Med. 2004 Oct 18;200(8):1001-13. [Abstract] [Full Text]
  • For research use only. Not for drug, diagnostic or other use.

    Related Products

  • Mouse Monoclonal to NTAL / LAB NAP-03 (IgG2a)
  • Rabbit Polyclonal to NTAL / LAB
  • Mouse Monoclonal to NTAL / LAB NAP-07 (IgG1)
  • Rabbit Polyclonal to NTAL / LAB
  • Example Data

    mNTAL N-terminal polyclonal
    Fig. 1. Western Blotting

    Fig. 1. Western Blotting analysis (non-reducing conditions) of mouse NTAL in mouse spleen tissue.
    Lane 1:
    immunostaining with polyclonal anti-NTAL antibody (cat. no. 11-487-C100)
    Lane 2:
    immunostaining with polyclonal anti-mouse NTAL antibody (specific for N-terminal domain of mouse NTAL)

    Unless indicated otherwise, all products are For Research Use Only and not for diagnostic or therapeutic use. Not for resale or transfer either as a stand-alone product or as a component of another product without written consent of EXBIO. EXBIO will not be held responsible for patent infringement or other violations that may occur with the use of our products. All orders are accepted subject to EXBIO´s term and conditions which are available at
    © 2003 EXBIO. All rights reserved.
    terms and conditions | privacy policy