Mouse Monoclonal to CD66e / CEA
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; 180-200 kDa) is a member of carcinoembryonic antigens, immunoglobulin supergene family and consists of a single N domain (structural homology to the immunoglobulin variable) and six immunoglobulin constant-like A (A1, A2, A3) and B domains (B1, B2, B3). Human CD66e is heavily glycosylated GPI anchored protein capable of both homophilic and heterophilic adhesion.
Disease relevance: The CD66e may play a role in the process of metastasis of cancer cells. CD66e is found in serum and it is clinically used as a tumor marker for early detection of disease due to its expression in adenocarcinomas - potential target of tumor imaging and drug targeting.
The antibody CB30 recognizes CD66e (CEA; 180-200 kDa), a cell surface bound carcinoembryonic antigen mainly expressed on epithelial cells.
Human carcinoembryonic antigen (CEA; CEACAM5)
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.
*Gangopadhyay A, Bajenova O, Kelly TM, Thomas P: Carcinoembryonic antigen induces cytokine expression in Kuppfer cells: implications for hepatic metastasis from colorectal cancer. Cancer Res. 1996 Oct 15;56(20):4805-10.
*Thompson JA, Grunert F, Zimmermann W: Carcinoembryonic antigen gene family: molecular biology and clinical perspectives. J Clin Lab Anal. 1991;5(5):344-66. Review.
*Oikawa S, Nakazato H, Kosaki G: Primary structure of human carcinoembryonic antigen (CEA) deduced from cDNA
sequence. Biochem Biophys Res Commun. 1987 Jan 30;142(2):511-8.
[Abstract] [Full Text]
*Chen CJ, Li LJ, Maruya A, Shively JE: In vitro and in vivo footprint analysis of the promoter of carcinoembryonic
antigen in colon carcinoma cells: effects of interferon gamma treatment. Cancer Res. 1995 Sep 1;55(17):3873-82.
For research use only. Not for drug, diagnostic or other use.
Mouse IgG1 Isotype Control
Fig. 1A Immunohistochemistry of paraffin-embedded sections (colorectal carcinoma)
Fig. 1B Immunohistochemistry of paraffin-embedded sections (colorectal carcinoma)
Fig. 1A, 1B:
Immunohistochemistry staining of colorectal carcinoma (paraffin-embedded sections) with
anti-human CD66e (CB30
Primary antibody dilution: 10 μg/ml.