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Mouse Monoclonal to IgM

MA2 (IgG2b)

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Immunoglobulin M (IgM) is produced as a 900 kDa pentamer, which is an efficient complement binder. This antibody type is produced initially in the immune response and it is the first immunoglobulin class to be synthesized by a fetus or newborn. IgM antibodies do not cross the placenta. IgM concentration in blood is 0.12 g/l and its biological survival (plasma T1/2) is 5 days.


The antibody MA2 reacts with µ-chain of human IgM, Fab - region localized epitope.

Regulatory Status


IgM from human serum.

Species Reactivity:

  • Human

Negative Species:


Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

General references

  • *Franklin E.C.: Structure and function of immunoglobulins. Acta Endocrinol Suppl (Copenh). 1975;194:77-95. [Abstract]
  • *Fuller JM, Keyser J.W.: Serum immunoglobulins after surgical operation. Clin Chem. 1975 May;21(6):667-71. [Abstract] [Full Text]
  • *Balogh Z, Merétey K, Falus A, Bozsóky S.: Serological abnormalities in juvenile chronic arthritis: a review of 46 cases. Ann Rheum Dis. 1980 Apr;39(2):129-34. [Abstract] [Full Text]
  • *Brinkmann V, Heusser CH.: T cell-dependent differentiation of human B cells into IgM, IgG, IgA, or IgE plasma cells: high rate of antibody production by IgE plasma cells, but limited clonal expansion of IgE precursors. Cell Immunol. 1993 Dec;152(2):323-32. [Abstract]
  • For research use only. Not for drug, diagnostic or other use.

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  • Mouse IgG2b Isotype Control
  • Example Data

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