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by categories | a-z list | Application type: Flow Cytometry | Immunohistochemistry | Functional Studies
categories: Hormones (Human)

Mouse Monoclonal to Thyroglobulin

2H11 (IgG1)

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Background

Thyroid disorders are often associated with autoimmune diseases and thyroid cancer.

Specificity

The antibody 2H11 recognizes antigen thyroglobulin (TG), a 610 kDa extracellular secreted glycoprotein specific to the thyroid gland. TG is mainly expressed on thyroid follicular cells (99,1 %).

Regulatory Status

Immunogen

thyroid follicular cells

Species Reactivity:

  • Human

Negative Species:

Applications:

  • Immunohistochemistry (paraffin sections)
    Recommended dilution: 1:80 - 1:100
    Pretreatment: Heat retrieval in 0.01M citrate buffer, pH 6 (microwave oven)
    Incubation: 1h at RT
    Positive tissue: thyroid gland, follicular adenoma
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

General references

  • Lazar V, Bidart JM, Caillou B, Mahe C, Lacroix L, Filetti S, Schlumberger M: Expression of the Na+/I- symporter gene in human thyroid tumors: a comparison study with other thyroid-specific genes. J Clin Endocrinol Metab. 1999 Sep;84(9):3228-34. [Abstract] [Full Text]
  • Hishinuma A, Takamatsu J, Ohyama Y, Yokozawa T, Kanno Y, Kuma K, Yoshida S, Matsuura N, Ieiri T: Two novel cysteine substitutions (C1263R and C1995S) of thyroglobulin cause a defect in intracellular transport of thyroglobulin in patients with congenital goiter and the variant type of adenomatous goiter. J Clin Endocrinol Metab. 1999 Apr;84(4):1438-44. [Abstract] [Full Text]
  • Emerson CH, Torres MS: Recombinant human thyroid-stimulating hormone: pharmacology, clinical applications and potential uses. BioDrugs. 2003;17(1):19-38. Review. [Abstract]
  • Product Specific References

  • *Magro G, Perissinotto D, Schiappacassi M, Goletz S, Otto A, Müller EC, Bisceglia M, Brown G, Ellis T, Grasso S, Colombatti A, Perris R: Proteomic and postproteomic characterization of keratan sulfate-glycanated isoforms of thyroglobulin and transferrin uniquely elaborated by papillary thyroid carcinomas. Am J Pathol. 2003 Jul;163(1):183-96. [Abstract]
  • For research use only. Not for drug, diagnostic or other use.

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  • Mouse IgG1 Isotype Control
  • Example Data

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