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Mouse Monoclonal to CD358 / DR6 / TNFRSF21

DR-6-04-EC (IgG1)

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  11-404-C025 purified 0.025 mg yes choose region PDF datasheetHTML datasheet buy
  11-404-C100 purified 0.1 mg yes choose region PDF datasheetHTML datasheet buy
  1F-404-C025 FITC 0.025 mg yes choose region PDF datasheetHTML datasheet buy
  1F-404-C100 FITC 0.1 mg yes choose region PDF datasheetHTML datasheet buy
  1P-404-C025 PE 0.025 mg yes choose region PDF datasheetHTML datasheet buy
  1P-404-C100 PE 0.1 mg yes choose region PDF datasheetHTML datasheet buy
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CD358 / DR6 (Death Receptor-6) is a type I transmembrane protein of the TNF receptor superfamily, expressed in most human tissues and able of inducing apoptosis through its cytoplasmic death domain. Unlike TNFR1 and Fas, DR6 induces apoptosis independently of FADD adaptor. In immune system, DR6 serves as an important regulator for CD4+ T cell proliferation and Th differentiation, and provides also a regulatory mechanism for B cell activation and humoral immune responses.


The antibody DR-6-04-EC recognizes human DR6 (Death receptor-6), a type I transmembrane protein containing cytoplasmic death domain, widely expressed in most human tissues and cell lines.
HLDA 9 workshop

Regulatory Status


A fusion protein representing amino acids 42-335 (extracellular part) of human DR6 linked to the Fc portion of human IgG1 was used as an immunogen.

Species Reactivity:

  • Human

Negative Species:


  • Flow Cytometry
    Recommended dilution:1 μg/ml
  • Immunoprecipitation
    Application note:
    The antibody DR-6-04-EC immunoprecipitates overexpressed DR6 from DR6-transfected HEK/293 cells.
  • Immunocytochemistry
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

General references

  • *Pan G, Bauer JH, Haridas V, Wang S, Liu D, Yu G, Vincenz C, Aggarwal BB, Ni J, Dixit VM: Identification and functional characterization of DR6, a novel death domain-containing TNF receptor. FEBS Lett. 1998 Jul 24;431(3):351-6. [Abstract]
  • *Kasof GM, Lu JJ, Liu D, Speer B, Mongan KN, Gomes BC, Lorenzi MV: Tumor necrosis factor-alpha induces the expression of DR6, a member of the TNF receptor family, through activation of NF-kappaB. Oncogene. 2001 Nov 29;20(55):7965-75. [Abstract] [Full Text]
  • *Rossi D, Gaidano G: Messengers of cell death: apoptotic signaling in health and disease. Haematologica. 2003 Feb;88(2):212-8. [Abstract] [Full Text]
  • *Schmidt CS, Liu J, Zhang T, Song HY, Sandusky G, Mintze K, Benschop RJ, Glasebrook A, Yang DD, Na S: Enhanced B cell expansion, survival, and humoral responses by targeting death receptor 6. J Exp Med. 2003 Jan 6;197(1):51-62. [Abstract] [Full Text]
  • For research use only. Not for drug, diagnostic or other use.

    Related Products

  • Recombinant human DR6 (TNFRSF21)/Fc Chimera
  • Mouse IgG1 Isotype Control
  • Example Data

    Fig. 1. Flow Cytometry analysis

    Fig. 1. Flow cytometry analysis of cell surface expression of DR6 in 6 different cell lines using purified anti-DR6 antibody (DR-6-04-EC) (detection by Goat anti-mouse IgG1 PE).

    DR6 ICC
    Fig. 2.

    Fig. 2. Detection of DR6 transiently transfected into HeLa cells (green) using anti-DR6 antibody (DR-6-04-EC). Cell nuclei visualized by DAPI (blue).

    1F-404 FITC

    Fig. 3. Flow cytometry analysis (surface staining) of DR6 in DR6-HeLa transfectants  using anti-DR6 antibody (DR-6-04-EC) FITC.

    Unless indicated otherwise, all products are For Research Use Only and not for diagnostic or therapeutic use. Not for resale or transfer either as a stand-alone product or as a component of another product without written consent of EXBIO. EXBIO will not be held responsible for patent infringement or other violations that may occur with the use of our products. All orders are accepted subject to EXBIO´s term and conditions which are available at
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