categories: CD and Related Antigens (Human), CD Antigens & MHC (Veterinary)

Mouse Monoclonal to CD41b

HIP2 (IgG3)

	Product No.	Form	Quantity	Stock	Price	Datasheet	Shop
	11-418-C025	purified	0.025 mg		choose region
	11-418-C100	purified	0.1 mg		choose region

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- Manufacture on order

Background

CD41 (platelet glycoprotein IIb) is composed of two subunits (120 kDa a, alpha and 23 kDa b, beta) that interact with CD61 in the presence of calcium to form a functional adhesive protein receptor. Upon blood vessel damage, this receptor binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin. CD41 is mainly expressed on megakaryocyte-platelet lineage, but generally belongs to the antigens that are expressed during early stages of hematopoietic differentiation.

Entrez Gene: 17q21.32

Specificity

The antibody HIP2 reacts with beta (b) subunit of CD41 glycoprotein (light chain; 23 kDa). CD41 is mainly expressed on platelets and megakaryocytes.
HLDA IV; WS Code P 39

Species Reactivity: Human Non-Human Primates Negative Species:	Applications: Flow Cytometry This HIP2 antibody has been tested by flow cytometric analysis of human platelets. This can be used at less than or equal to 1 μg per 100 μl blood. Immunohistochemistry (frozen sections) Usage note: Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.	General references Debili N, Robin C, Schiavon V, Letestu R, Pflumio F, Mitjavila-Garcia MT, Coulombel L, Vainchenker W: Different expression of CD41 on human lymphoid and myeloid progenitors from adults and neonates. Blood. 2001 Apr 1;97(7):2023-30. [Abstract] Mitjavila-Garcia MT, Cailleret M, Godin I, Nogueira MM, Cohen-Solal K, Schiavon V, Lecluse Y, Le Pesteur F, Lagrue AH, Vainchenker W: Expression of CD41 on hematopoietic progenitors derived from embryonic hematopoietic cells. Development. 2002 Apr;129(8):2003-13. [Abstract] Ferkowicz MJ, Starr M, Xie X, Li W, Johnson SA, Shelley WC, Morrison PR, Yoder MC: CD41 expression defines the onset of primitive and definitive hematopoiesis in the murine embryo. Development. 2003 Sep;130(18):4393-403. [Abstract] Zhang J, Varas F, Stadtfeld M, Heck S, Faust N, Graf T: CD41-YFP mice allow in vivo labeling of megakaryocytic cells and reveal a subset of platelets hyperreactive to thrombin stimulation. Exp Hematol. 2007 Mar;35(3):490-499. [Abstract] Product Specific References Chen Z., Bao ZX., Yu AX. et al. (1987): A group monoclonal antibodies against human platelets with different functions. Chinese Science Bulletin. 24:1902 Bao CX., Chen Z., Jin XQ. et al. (1987): HIP2: A new monoclonal antibody with stimulation for human platelet. Chinese J. of Hematology. 8(2):65 Wu XW., Chen Z., Bao CX. et al. (1989): Production and application of anti-human platelet GPIIb/IIIa monoclonal antibodies. National Medical J. of China. 69(8):427 Leukocyte Typing IV., Knapp W. et al. (Eds.), Oxford University Press (1989). Bao CX., Liu JW., Chen GZ. et al. (1992): Some biological characterization of monoclonal antibody HIP2 receptor on platelet membrane glycoprotein IIB. Chinese J. of Hematology.13(2):66 Leukocyte Typing V., Schlossman S. et al. (Eds.), Oxford University Press (1995). *Leukocyte Typing VI., Kishimoto T. et al. (Eds.), Garland Publishing Inc. (1997).

Species Reactivity:

Human
Non-Human Primates

Negative Species:

Applications:

Flow Cytometry
This HIP2 antibody has been tested by flow cytometric analysis of human platelets. This can be used at less than or equal to 1 μg per 100 μl blood.
Immunohistochemistry (frozen sections)

Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

General references

*Debili N, Robin C, Schiavon V, Letestu R, Pflumio F, Mitjavila-Garcia MT, Coulombel L, Vainchenker W: Different expression of CD41 on human lymphoid and myeloid progenitors from adults and neonates. Blood. 2001 Apr 1;97(7):2023-30. [Abstract]

*Mitjavila-Garcia MT, Cailleret M, Godin I, Nogueira MM, Cohen-Solal K, Schiavon V, Lecluse Y, Le Pesteur F, Lagrue AH, Vainchenker W: Expression of CD41 on hematopoietic progenitors derived from embryonic hematopoietic cells. Development. 2002 Apr;129(8):2003-13. [Abstract]

*Ferkowicz MJ, Starr M, Xie X, Li W, Johnson SA, Shelley WC, Morrison PR, Yoder MC: CD41 expression defines the onset of primitive and definitive hematopoiesis in the murine embryo. Development. 2003 Sep;130(18):4393-403. [Abstract]

*Zhang J, Varas F, Stadtfeld M, Heck S, Faust N, Graf T: CD41-YFP mice allow in vivo labeling of megakaryocytic cells and reveal a subset of platelets hyperreactive to thrombin stimulation. Exp Hematol. 2007 Mar;35(3):490-499. [Abstract]

Product Specific References

*Chen Z., Bao ZX., Yu AX. et al. (1987): A group monoclonal antibodies against human platelets with different functions. Chinese Science Bulletin. 24:1902

*Bao CX., Chen Z., Jin XQ. et al. (1987): HIP2: A new monoclonal antibody with stimulation for human platelet. Chinese J. of Hematology. 8(2):65

*Wu XW., Chen Z., Bao CX. et al. (1989): Production and application of anti-human platelet GPIIb/IIIa monoclonal antibodies. National Medical J. of China. 69(8):427

*Leukocyte Typing IV., Knapp W. et al. (Eds.), Oxford University Press (1989).

*Bao CX., Liu JW., Chen GZ. et al. (1992): Some biological characterization of monoclonal antibody HIP2 receptor on platelet membrane glycoprotein IIB. Chinese J. of Hematology.13(2):66

*Leukocyte Typing V., Schlossman S. et al. (Eds.), Oxford University Press (1995).

*Leukocyte Typing VI., Kishimoto T. et al. (Eds.), Garland Publishing Inc. (1997).

For research use only. Not for drug, diagnostic or other use.

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