Mouse Monoclonal to HLA-E
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The antibody MEM-E/07 recognized native surface-expressed HLA-E, but not denaturated heavy chain of HLA-E. HLA-E belongs to the MHC Class I molecules (MHC Class Ib; nonclassical) and it is expressed on many types of the human cells.
The published results revealed that the antibody cross-reacts with some classical MHC Class I molecules (MHC Class Ia): HLA-B7 (strongly), HLA-B8 (moderately), HLA-B27, -B44 (weakly).
Bacterially expressed recombinant HLA-E refolded with beta2-microglobulin and peptide.
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.
Product Specific References
*Sibilio L. et al., Tissue Antigens 62, 339, 2003. (Abstract 45 from the 3rd Int. Conference on HLA-G, Paris, July 2003).
*Palmisano GL, Contardi E, Morabito A, Gargaglione V, Ferrara GB, Pistillo MP: HLA-E surface expression is independent of the availability of HLA class I signal sequence-derived peptides in human tumor cell lines.
Hum Immunol. 2005 Jan;66(1):1-12. [Abstract] [Full Text]
For research use only. Not for drug, diagnostic or other use.
Mouse IgG1 Isotype Control
Immunohistochemistry staining of human spleen (paraffin sections) with anti-HLA-E (clone MEM-E/07
Commercially tested by LifeSpan BioSciences.