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Mouse Monoclonal to IgG (Fab)

4A11 (IgG2b)

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  T8-319-T025 PE-Cy™5 25 tests yes choose region PDF datasheetHTML datasheet buy
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Background

Immunoglobulin G (IgG) is a 150 kDa soluble protein that serves as a major effector molecule of the humoral immune response in man. Its concentration in blood plasma of healthy individuals is approximately 10 g/l, which accounts for about 75% of the total plasma immunoglobulins. IgG has the highest stability of blood immunoglobulins (T1/2 = 21 days) and is able of placental transfer. IgG is secreted by plasma cells at a comparably high rate as other immunoglobulins.

Specificity

The antibody 4A11 reacts with Fab fragment of human IgG.

Regulatory Status

Immunogen

Purified human IgG.

Species Reactivity:

  • Human

Negative Species:

Applications:

  • Flow Cytometry
  • Western Blotting
  • ELISA
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

General references

  • *Franklin EC: Structure and function of immunoglobulins. Acta Endocrinol Suppl (Copenh). 1975;194:77-95. [Abstract]
  • *Fuller JM, Keyser JW: Serum immunoglobulins after surgical operation. Clin Chem. 1975 May;21(6):667-71. [Abstract] [Full Text]
  • *Balogh Z, Merétey K, Falus A, Bozsóky S: Serological abnormalities in juvenile chronic arthritis: a review of 46 cases. Ann Rheum Dis. 1980 Apr;39(2):129-34. [Abstract] [Full Text]
  • *Brinkmann V, Heusser CH: T cell-dependent differentiation of human B cells into IgM, IgG, IgA, or IgE plasma cells: high rate of antibody production by IgE plasma cells, but limited clonal expansion of IgE precursors. Cell Immunol. 1993 Dec;152(2):323-32. [Abstract]
  • For research use only. Not for drug, diagnostic or other use.

    Related Products

  • Mouse IgG2b Isotype Control
  • Example Data


    4A11



    Fig. 1. Western Blotting analysis (reducing conditions) of human IgG Fab fragment using anti-human IgG Fab fragment (4A11).
    Lane 1: Normal human immunoglobulins
    Lane 2: Normal bovine immunoglobulins



    4A11 PE FC

    Fig. 2. Surface staining of human peripheral blood cells with anti-human IgG Fab fragment (4A11) PE.


    4A11 purified

    Fig. 3. Surface staining of human peripheral blood cells with anti-human IgG Fab fragment (4A11) purified / GAM-APC.


    4A11 PE-Cy7

    Fig. 4. Surface staining of human peripheral blood cells with anti-human IgG Fab fragment (4A11) PE-CyTM7.


    4A11 PE-Cy5

    Fig. 5. Surface staining of human peripheral blood cells with anti-human IgG Fab fragment (4A11) PE-CyTM5.

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