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Mouse Monoclonal to Benzo[a]pyrene

BAP-13 (IgG1)

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Specificity

The antibody BAP-13 is specific for Polynuclear Aromatic Hydrocarbons.
The antibody BAP-13 inhibits DNA adduct formation (this ability was investigated in rat liver microsomes spiked with calf thymus DNA and 7,8-diol-B[a]P).

Regulatory Status

Immunogen

Benzo[a]pyrenyl-1-butyric acid conjugated to BSA.

Species Reactivity:

Negative Species:

Applications:

  • Immunocytochemistry
    The antibody BAP-13 is suitable for immunocytochemical analysis of DNA and protein adducts of benzo[a]pyrene in tissues of various species.
  • ELISA
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

Product Specific References

  • *Suchanek M, Scharnweber T, Fisher M, Knopp D, Niessner R: Monoclonal antibodies specific to polynuclear aromatic hydrocarbons. Folia Biol (Praha). 2001;47(3):106-7.
  • *Scharnweber T, Fisher M, Suchanek M, Knopp D, Niessner R: Monoclonal antibody to polycyclic aromatic hydrocarbons based on a new benzo[a]pyrene immunogen. Fresenius J Anal Chem. 2001 Nov;371(5):578-85. [Abstract]
  • *De Buck SS, Bouche FB, Brandenburger A, Muller CP: Modulation of the metabolism and adverse effects of benzo[a]pyrene by a specific antibody: a novel host factor in environmental carcinogenesis? Carcinogenesis. 2005 Apr;26(4):835-44. [Abstract] [Full Text]
  • For research use only. Not for drug, diagnostic or other use.

    Related Products

  • Mouse IgG1 Isotype Control
  • Example Data

    BAP-13 pur


    Fig. 1. ELISA detection of benzo(a)pyrene using mouse monoclonal antibody BAP-13, compared with isotype control antibody PPV-06.

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