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Mouse Monoclonal to Cytokeratin 19

BA-17 (IgG1)

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Background

Cytokeratins are a subfamily of intermediate filaments and characterized by remarkable biochemical diversity. Cytokeratins are represented in epithelial tissues by at least 20 different polypeptides, molecular weight between 40 kDa and 68 kDa. The individual cytokeratin polypeptides are designated 1 to 20 and divided into the type I (acidic cytokeratins 9-20) and type II (basic to neutral cytokeratins 1-8) families.

Specificity

The antibody BA-17 reacts with cytokeratin 19 (40 kDa) in human tissue. Cytokeratin 19 is not expressed in hepatocytes; it is often co-expressed with cytokeratin 7.

Regulatory Status

Immunogen

Mammary organoids.

Species Reactivity:

  • Human

Negative Species:

Applications:

  • Western Blotting
  • Immunohistochemistry (paraffin sections)
  • Flow Cytometry
  • Immunoprecipitation
  • Immunocytochemistry
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

Product Specific References

  • *Bartek J, Durban EM, Hallowes RC, Taylor-Papadimitriou J: A subclass of luminal epithelial cells in the human mammary gland, defined by antibodies to cytokeratins. J Cell Sci. 1985 Apr;75:17-33. [Abstract]
  • *Bartek J, Taylor-Papadimitriou J, Miller N, Millis R: Patterns of expression of keratin 19 as detected with monoclonal antibodies in human breast tissues and tumours. Int J Cancer. 1985 Sep 15;36(3):299-306. [Abstract]
  • *Lewis BC, Klimstra DS, Varmus HE: The c-myc and PyMT oncogenes induce different tumor types in a somatic mouse model for pancreatic cancer. Genes Dev. 2003 Dec 15;17(24):3127-38. Epub 2003 Dec 17. [Abstract] [Full Text]
  • For research use only. Not for drug, diagnostic or other use.

    Related Products

  • Mouse IgG1 Isotype Control
  • Example Data

    cytokeratin 19 WB
    Fig. 1.


    Fig. 1. Detection of cytokeratin 19 in MCF-7 cell lysate by mouse monoclonal antibody BA-17.

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