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Mouse Monoclonal to Cytokeratin 8

C-43 (IgG1)

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Cytokeratins are a subfamily of intermediate filaments and characterized by remarkable biochemical diversity. Cytokeratins are represented in epithelial tissues by at least 20 different polypeptides, molecular weight between 40 kDa and 68 kDa. The individual cytokeratin polypeptides are designated 1 to 20 and divided into the type I (acidic cytokeratins 9-20) and type II (basic to neutral cytokeratins 1-8) families.


The antibody C-43 reacts with Cytokeratin 8 (52.5 kDa). Cytokeratins are a member of intermediate filaments subfamily represented in epithelial tissues.

Regulatory Status


Cytoskeleton preparation from HeLa human cervix carcinoma cell line.

Species Reactivity:

  • Human
  • Porcine
  • Bovine
  • Sheep
  • Rabbit

Negative Species:

  • Mouse
  • Rat
  • Hamster
  • Chicken
  • Xenopus


  • Immunoprecipitation
  • Western Blotting
  • Immunohistochemistry (paraffin sections)
    Recommended dilution: 20 μg/ml
    Positive tissue: prostate
  • Immunocytochemistry
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

Product Specific References

  • *Kovarik J et al.: J Tumor Marker Oncol. 5, 219 (1990).
  • *Bartek J, Vojtesek B, Staskova Z, Bartkova J, Kerekes Z, Rejthar A, Kovarik J: A series of 14 new monoclonal antibodies to keratins: characterization and value in diagnostic histopathology. J Pathol. 1991 Jul;164(3):215-24. [Abstract]
  • *Sikorski K, Mehta A, Inngjerdingen M, Thakor F, Kling S, Kalina T, Nyman TA, Stensland ME, Zhou W, de Souza GA, Holden L, Stuchly J, Templin M, Lund-Johansen F: A high-throughput pipeline for validation of antibodies. Nat Methods. 2018 Nov;15(11):909-912. [Abstract]
  • For research use only. Not for drug, diagnostic or other use.

    Related Products

  • Mouse IgG1 Isotype Control
  • Example Data

    C-43 pur WB

    Fig. 1. Detection of cytokeratin 8 in HeLa cell lysate (reducing conditions) by mouse monoclonal antibody C-43.

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