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Mouse Monoclonal to Insulin

IN-05 (IgG1)

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Background

Insulin and glucagon are pancreatic endocrine hormones secreted by islet cells within the pancreas. The stimulus for insulin secretion is a HIGH blood glucose. Deficiency of insulin results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population.

Specificity

The antibody IN-05 reacts with insulin, one of the major regulatory endocrine hormones of intermediate metabolism, normally secreted by the beta cells (a type of islet cells) of the pancreas; it is also present in tumors of B cell origin such as insulinoma.

Regulatory Status

Immunogen

Porcine insulin.

Species Reactivity:

  • Human
  • Porcine
  • Bovine

Negative Species:

Applications:

  • ELISA
  • RIA
  • Immunohistochemistry (paraffin sections)
  • Immunocytochemistry
  • Functional Application
    The antibody IN-05 blocks binding of insulin to the receptor.
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

Product Specific References

  • *Horejsi V, Hilgert I, Kristofova H, Satayalai O: Murine hybridoma monoclonal antibodies against insulin: cross-reactivity with insulins of three species and blocking of insulin binding to its receptor. Immunol Lett. 1984;8(5):279-83. [Abstract]
  • For research use only. Not for drug, diagnostic or other use.

    Related Products

  • Mouse IgG1 Isotype Control
  • Example Data

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