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Mouse Monoclonal to IgA

AD3 (IgG1)

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  11-322-C025 purified 0.025 mg yes choose region PDF datasheetHTML datasheet buy
  11-322-C100 purified 0.1 mg yes choose region PDF datasheetHTML datasheet buy
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Background

Immunoglobulin A (IgA) is the major immunoglobulin class in body secretions that protects against infections of the mucous membranes lining the mouth, airways, and digestive tract. Its serum concentration is approximately 0.2 g/l and biological survival (T1/2 in plasma) 6 days. Plasma IgA is predominantly monomeric (160 kDa) and of the IgA1 subclass, and is mostly produced in the bone marrow. Over half of IgA produced by the intestinal lamina propria plasmocytes is in oligomeric form and 35% of it is IgA2.

Specificity

The antibody AD3 reacts with alpha-chain of human IgA1 and IgA2.

Regulatory Status

Immunogen

Purified human IgA.

Species Reactivity:

  • Human

Negative Species:

Applications:

  • Immunohistochemistry (paraffin sections)
    Recommended dilution:10 μg/ml
    Positive tissue: colon
  • ELISA
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

General references

  • *Franklin EC: Structure and function of immunoglobulins. Acta Endocrinol Suppl (Copenh). 1975;194:77-95. [Abstract]
  • *Fuller JM, Keyser JW: Serum immunoglobulins after surgical operation. Clin Chem. 1975 May;21(6):667-71. [Abstract] [Full Text]
  • *Balogh Z, Merétey K, Falus A, Bozsóky S: Serological abnormalities in juvenile chronic arthritis: a review of 46 cases. Ann Rheum Dis. 1980 Apr;39(2):129-34. [Abstract] [Full Text]
  • *Jonard PP, Rambaud JC, Dive C, Vaerman JP, Galian A, Delacroix DL: Secretion of immunoglobulins and plasma proteins from the jejunal mucosa. Transport rate and origin of polymeric immunoglobulin A. J Clin Invest. 1984 Aug;74(2):525-35. [Abstract] [Full Text]
  • For research use only. Not for drug, diagnostic or other use.

    Related Products

  • Mouse IgG1 Isotype Control
  • Example Data


    AD3
    Fig. 1.


    Fig. 1. Immunohistochemistry staining of human colon (paraffin sections) with anti-IgA (clone AD3).
    Commercially tested by LifeSpan BioSciences.

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