Mouse Monoclonal to HLA-Class I
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major histocompatibility (MHC) antigens are intrinsic membrane glycoproteins expressed on nucleated cells and noncovalently associated with an invariant beta2 microglobulin. They carry foreign determinants important for immune recognition by cytotoxic T cells, thus important for anti-viral and anti-tumour defence. Human HLA-class I antigens are represented by HLA-A
Entrez Gene (HLA-A; human): 6p21.3
Entrez Gene (HLA-B; human): 6p21.3
Entrez Gene (HLA-C; human): 6p21.3
The antibody MEM-123 reacts with all human classical MHC Class I molecules (major histocompatibility complex) in native cell-surface forms as well as with human HLA-G cDNA transfected cells. MHC Class I molecules (MHC Class Ia) are expressed on the surface of all human cell types.
The antibody MEM-123 completely blocks binding of classical W6/32 to surface-expressed HLA-G, but does not cross-blocks the antibody MEM-G/9.
COS-7 African green monkey kidney cells
- Non-Human Primates
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.
For research use only. Not for drug, diagnostic or other use.
Mouse IgG3 Isotype Control
Surface staining of human peripheral blood with anti-HLA-class I (MEM-123
) purified, GAM-APC.
Surface staining of K562 cells with anti-HLA-class I (MEM-123