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Mouse Monoclonal to HLA-E

MEM-E/02 (IgG1)

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  11-361-C025 purified 0.025 mg yes choose region PDF datasheetHTML datasheet buy
  11-361-C100 purified 0.1 mg yes choose region PDF datasheetHTML datasheet buy
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Background

Specificity

The antibody MEM-E/02 specifically reacts with denaturated heavy chain of human HLA-E. HLA-E belongs to the MHC Class I molecules (MHC Class Ib; nonclassical) and it is expressed on the surface of all human cell types.

Regulatory Status

Immunogen

Recombinant human HLA-E denaturated heavy chain.

Species Reactivity:

  • Human
  • Non-Human Primates

Negative Species:

Applications:

  • Western Blotting
  • Immunohistochemistry (paraffin sections)
    Recommended dilution: 5-10 μg/ml
    Positive control:Human placenta
    Application note:Heat antigen retrieval (sodium citrate); incubation with mAb: 1 hour / RT; detection DAB
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

Product Specific References

  • *Menier C, Saez B, Horejsi V, Martinozzi S, Krawice-Radanne I, Bruel S, Le Danff C, Reboul M, Hilgert I, Rabreau M, Larrad ML, Pla M, Carosella ED, Rouas-Freiss N: Characterization of monoclonal antibodies recognizing HLA-G or HLA-E: new tools to analyze the expression of nonclassical HLA class I molecules. Hum Immunol. 2003 Mar;64(3):315-26. [Abstract]
  • *Dambaeva SV, Bondarenko GI, Grendell RL, Kravitz RH, Durning M, Golos TG: Non-classical MHC-E (Mamu-E) expression in the rhesus monkey placenta. Placenta. 2008 Jan;29(1):58-70. [Abstract] [Full Text]
  • *Lo Monaco E, Tremante E, Cerboni C, Melucci E, Sibilio L, Zingoni A, Nicotra MR, Natali PG, Giacomini P: Human leukocyte antigen E contributes to protect tumor cells from lysis by natural killer cells. Neoplasia. 2011 Sep;13(9):822-30. [Abstract] [Full Text]
  • For research use only. Not for drug, diagnostic or other use.

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