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Mouse Monoclonal to CD108 / Semaphorin 7a

MEM-150 (IgM)

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CD108 (Sema7A) is a GPI-anchored semaphorin family member, which enhances central and peripheral axonal growth and is required for proper axon track formation during ebryogenesis. CD108 also regulates osteoclast differentiation and pre-osteoblastic cell migration, and in immune system affects cell proliferation, chemotaxis and cytokine release. On erythrocytes CD108 defines the JMH (John-Milton-Hagen) human blood group. CD108 signalizes through its receptors – plexin C1 and beta1 integrins.


The antibody MEM-150 reacts with CD108 (JMH blood group antigen), a 80 kDa GPI-anchored glycoprotein expressed on various cell types including erythrocytes, lymphoblasts; at low levels it is present on circulating lymphocytes.
HLDA V; WS Code AS S017
HLDA V; WS Code BP BP347
HLDA VI; WS Code BP 401
HLDA VI; WS Code BP 475
HLDA VI; WS Code NL N-L156
HLDA VI; WS Code P PR-65

Regulatory Status


HPB-ALL human T cell line

Species Reactivity:

  • Human

Negative Species:


  • Flow Cytometry
    Recommended dilution:4 μg/ml
  • Immunoprecipitation
  • Western Blotting
    Application note: Non-reducing conditions.
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

General references

  • *Pasterkamp RJ, Peschon JJ, Spriggs MK, Kolodkin AL: Semaphorin 7A promotes axon outgrowth through integrins and MAPKs. Nature. 2003 Jul 24;424(6947):398-405. [Abstract]
  • *Delorme G, Saltel F, Bonnelye E, Jurdic P, Machuca-Gayet I: Expression and function of semaphorin 7A in bone cells. Biol Cell. 2005 Jul;97(7):589-97. [Abstract]
  • *Pasterkamp RJ, Kolk SM, Hellemons AJ, Kolodkin AL: Expression patterns of semaphorin7A and plexinC1 during rat neural development suggest roles in axon guidance and neuronal migration. BMC Dev Biol. 2007 Aug 29;7:98. [Abstract] [Full Text]
  • *Suzuki K, Okuno T, Yamamoto M, Pasterkamp RJ, Takegahara N, Takamatsu H, Kitao T, Takagi J, Rennert PD, Kolodkin AL, Kumanogoh A, Kikutani H: Semaphorin 7A initiates T-cell-mediated inflammatory responses through alpha1beta1 integrin. Nature. 2007 Apr 5;446(7136):680-4. [Abstract]
  • Product Specific References

  • *Mudad R, Rao N, Angelisova P, Horejsi V, Telen MJ.: Evidence that CDw108 membrane protein bears the JMH blood group antigen. Transfusion. 1995 Jul;35(7):566-70. [Abstract]
  • *Leukocyte Typing V., Schlossman S. et al. (Eds.), Oxford University Press (1995).
  • *Leukocyte Typing VI., Kishimoto T. et al. (Eds.), Garland Publishing Inc. (1997).
  • *Angelisova P, Drbal K, Cerny J, Hilgert I, Horejsi V: Characterization of the human leukocyte GPI-anchored glycoprotein CDw108 and its relation to other similar molecules. Immunobiology. 1999 Jun;200(2):234-45. [Abstract]
  • For research use only. Not for drug, diagnostic or other use.

    Related Products

  • Mouse IgM Isotype Control
  • Example Data

    Fig. 1. Flow Cytometry analysis

    Fig. 1. Surface staining of HPB-ALL human peripheral blood T cell leukemia cell line with anti-human CD108 (MEM-150) FITC.
    Total viable cells were used for analysis.

    MEM-150 pur

    Fig. 2. Surface staining of human peripheral blood with anti-human CD108 (MEM-150) purified, GAM IgM PE.

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