Mouse Monoclonal to CD54 / ICAM-1
MEM-112 (IgG1)
Technical Information Request Inquiry for Bulk Prices
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Product No. |
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Stock |
Price |
Datasheet |
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11-229-C025 |
purified |
0.025 mg |
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choose region |
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11-229-C100 |
purified |
0.1 mg |
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choose region |
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- In stock! Ready for immediate despatch
- Manufacture on order
Background
CD54 (ICAM-1) is a 90 kD member of the C2 subset of immunoglobulin superfamily. It is a transmembrane molecule with 7 potential N-glycosylated sites, expressed on resting monocytes and endothelial cells and can be upregulated on many other cells, e.g. with lymphokines, on B- and T-lymphocytes, thymocytes, dendritic cells and also on keratinocytes, chondrocytes, as well as epithelial cells. CD54 mediates cell adhesion by binding to integrins CD11a/CD18 (LFA-1) and to CD11b/CD18 (Mac-1). The interaction of CD54 with LFA-1 enhances antigen-specific T-cell activation.
Specificity
The antibody MEM-112 reacts with CD54 (ICAM-1), a 85-110 kDa type I transmembrane glycoprotein (receptor for rhinovirus). The expression of CD54 is upregulated by activation; it is expressed on activated endothelial cells, T lymphocytes, B lymphocytes, monocytes, macrophages, granulocytes and dendritic cells.
HLDA VI; WS Code AS A050
Immunogen
Raji Burkitt's lymphoma cell line Raji
Species Reactivity:
Negative Species:
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Applications:
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.
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Product Specific References
*Leeuwenberg JF, Smeets EF, Neefjes JJ, Shaffer MA, Cinek T, Jeunhomme TM, Ahern TJ, Buurman WA.: E-selectin and intercellular adhesion molecule-1 are released by activated
human endothelial cells in vitro. Immunology. 1992 Dec;77(4):543-9. [Abstract]
*Leukocyte Typing VI., Kishimoto T. et al. (Eds.), Garland Publishing Inc. (1997).
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For research use only. Not for drug, diagnostic or other use.
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