Mouse Monoclonal to HLA-Class I
MEM-123 (IgG3)
Technical Information Request Inquiry for Bulk Prices
- In stock! Ready for immediate despatch
- Manufacture on order
Background
HLA-class I major histocompatibility (MHC) antigens are intrinsic membrane glycoproteins expressed on nucleated cells and noncovalently associated with an invariant beta2 microglobulin. They carry foreign determinants important for immune recognition by cytotoxic T cells, thus important for anti-viral and anti-tumour defence. Human HLA-class I antigens are represented by HLA-A, HLA-B and HLA-C molecules.
Entrez Gene (HLA-A; human):
6p21.3Entrez Gene (HLA-B; human):
6p21.3Entrez Gene (HLA-C; human):
6p21.3
Specificity
The antibody MEM-123 reacts with all human classical MHC Class I molecules (major histocompatibility complex) in native cell-surface forms as well as with human HLA-G cDNA transfected cells. MHC Class I molecules (MHC Class Ia) are expressed on the surface of all human cell types.
The antibody MEM-123 completely blocks binding of classical W6/32 to surface-expressed HLA-G, but does not cross-blocks the antibody MEM-G/9.
Immunogen
COS-7 African green monkey kidney cells
Species Reactivity:
- Human
- Non-Human Primates
- Bovine
Negative Species:
|
Applications:
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.
|
References
Unpublished.
|
For research use only. Not for drug, diagnostic or other use.
Related Products
Mouse IgG3 Isotype Control
