Mouse Monoclonal to Gamma-tubulin complex component 2
GCP2-01 (IgG2b)
Technical Information Request Inquiry for Bulk Prices
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Product No. |
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Datasheet |
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11-695-C025 |
purified |
0.025 mg |
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choose region |
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11-695-C100 |
purified |
0.1 mg |
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choose region |
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- In stock! Ready for immediate despatch
- Manufacture on order
Background
Gamma tubulin complex component 2 (GCP2) is 95-103 kDa protein which associates with two molecules of gamma tubulin and one molecule of gamma tubulin complex component 3 (GCP3), to form the gamma tubulin small complexes (gammaTuSCs). These complexes interact with GCP4, 5, and 6 to form the gamma tubulin ring complexes (gammaTuRCs), which are embedded in the microtubule organizing center matrix where they nucleate microtubules. The gammaTuRCs are also involved in the regulation of microtubule plus and minus end dynamics. Components of gamma tubulin complexes are highly conservative in eukaryotes.
Specificity
The mouse monoclonal antibody GCP2-01 recognizes gamma-tubulin complex component 2 (GCP2), a 95-103 kDa protein. It recognizes also phosphorylated GCP2.
Immunogen
GST-fusion protein containing amino acids 2-194 of mouse GCP2
Species Reactivity:
Negative Species:
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Applications:
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.
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General references
*Bouissou A, Vérollet C, Sousa A, Sampaio P, Wright M, Sunkel CE, Merdes A, Raynaud-Messina B. {gamma}-Tubulin ring complexes regulate microtubule plus end dynamics. J Cell Biol. 2009 Nov 2;187(3):327-34. [Abstract] [Full Text]
Product Specific References
*Hořejší B, Vinopal S, Sládková V, Dráberová E, Sulimenko V, Sulimenko T, Vosecká V, Philimonenko A, Hozák P, Katsetos CD, Dráber P: Nuclear γ-tubulin associates with nucleoli and interacts with tumor suppressor protein C53. J Cell Physiol. 2012 Jan;227(1):367-82. [Abstract]
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For research use only. Not for drug, diagnostic or other use.
