|Source:||Produced in HEK 293 cells. The extracellular domain of human DR6 (aa 1 - 212) is fused to the Fc portion of human IgG1.|
|Description:||Human DR6 (Death Receptor-6; TNFRSF21) is a type I transmembrane protein containing cytoplasmic death domain, member of the TNF receptor superfamily, expressed in most human tissues.|
|Purity:||> 95% (by SDS-PAGE)|
|Purification:||Purified from cell culture supernatant by protein-A affinity chromatography.|
|M.W.:||The recombinant human DR6/Fc chimera has a calculated molecular mass of 40 kDa. As a result of glycosylation, the recombinant protein migrates as a 50 kDa protein in SDS-PAGE under reducing condisions.|
|Endotoxin level:||< 0.01 EU/µg purified protein as determined by LAL test.|
|Formulation:||Lyophilized from a 0.22 µm filtered solution in PBS.|
|Reconstitution:||Reconstitute with 50 µl sterile deionized water. For long term storage or for preparation of more diluted working stock solution, a carrier protein (e.g. 1% serum albumin) should be added to the vial.|
|Storage / Stability:||Store lyophilized product in freezer (-20 °C to -80 °C). The expiration date of unopened product vial is indicated on the vial label. After reconstitution prepare suitable aliquots. Reconstituted product is stable for at least 6 months when stored in freezer (-20 °C to -80 °C). Avoid freeze/thaw cycles.|
Pan G. et al., Identification and functional characterization of DR6, a novel death domain-containing TNF receptor. FEBS Lett. 1998 431(3):351-6.
For laboratory research only, not for drug, diagnostic or other use.
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