EXBIO Antibodies Product Data Sheet


Recombinant human DR6 (TNFRSF21)/Fc Chimera
Lyophilized (0.05 mg)

Source: Produced in HEK 293 cells. The extracellular domain of human DR6 (aa 1 - 212) is fused to the Fc portion of human IgG1.
Description: Human DR6 (Death Receptor-6; TNFRSF21) is a type I transmembrane protein containing cytoplasmic death domain, member of the TNF receptor superfamily, expressed in most human tissues.
Regulatory Status: RUO
Purity: > 95% (by SDS-PAGE)
Purification: Purified from cell culture supernatant by protein-A affinity chromatography.
M.W.: The recombinant human DR6/Fc chimera has a calculated molecular mass of 40 kDa. As a result of glycosylation, the recombinant protein migrates as a 50 kDa protein in SDS-PAGE under reducing condisions.
Endotoxin level: < 0.01 EU/µg purified protein as determined by LAL test.
Formulation: Lyophilized from a 0.22 µm filtered solution in PBS.
Reconstitution: Reconstitute with 50 µl sterile deionized water. For long term storage or for preparation of more diluted working stock solution, a carrier protein (e.g. 1% serum albumin) should be added to the vial.
Storage / Stability: Store lyophilized product in freezer (-20 C to -80 C). The expiration date of unopened product vial is indicated on the vial label. After reconstitution prepare suitable aliquots. Reconstituted product is stable for at least 6 months when stored in freezer (-20 C to -80 C). Avoid freeze/thaw cycles.
Pan G. et al., Identification and functional characterization of DR6, a novel death domain-containing TNF receptor. FEBS Lett. 1998 431(3):351-6.
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For laboratory research only, not for drug, diagnostic or other use.

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