EXBIO Antibodies Product Data Sheet

11-128-C100

Monoclonal Antibody to Lactoferrin
Purified Antibody (0.1 mg)

Clone: LF5-1D2
Isotype: Mouse IgG1
Specificity: The mouse monoclonal antibody LF5-1D2 recognizes lactoferrin, an iron-binding glycoprotein of about 90 kDa, which has anti-inflammatory, immunomodulatory and anti-microbial properties.
Regulatory Status: RUO
Immunogen: human lactoferrin
Species Reactivity: Human
Application:
Flow Cytometry
intracellular
ELISA
Purity: > 95% (by SDS-PAGE)
Purification: Purified from hybridoma culture supernatant by protein-A affinity chromatography.
Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Storage / Stability: Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.
Expiration: See vial label
Lot Number: See vial label
Background: Lactoferrin is an iron-binding glycoprotein of the transferrin family, which is released to most biological fluids, with particularly high levels in milk. It has anti-inflammatory (e.g. sequestering of lipopolysaccharides), anti-microbial (e.g. blocking of viral attachment to the target cell), and immunomodulatory properties and can prevent infections in young children. Lactoferrin is considered to bridge the innate and adaptive immune responses. It also participates in iron homeostasis, regulation of cellular growth and differentiation and protection against cancer development and metastasis. Besides biological fluids it is also found in the secondary granules of neutrophils.
References:
Wakabayashi H, Oda H, Yamauchi K, Abe F: Lactoferrin for prevention of common viral infections. J Infect Chemother. 2014 Aug 30. pii: S1341-321X(14)00286-4.
*Turin CG, Zea-Vera A, Pezo A, Cruz K, Zegarra J, Bellomo S, Cam L, Llanos R, Castañeda A, Tucto L, Ochoa TJ; NEOLACTO Research Group: Lactoferrin for prevention of neonatal sepsis. Biometals. 2014 Oct;27(5):1007-16. doi: 10.1007/s10534-014-9754-3.
*Siqueiros-Cendón T, Arévalo-Gallegos S, Iglesias-Figueroa BF, García-Montoya IA, Salazar-Martínez J, Rascón-Cruz Q: Immunomodulatory effects of lactoferrin. Acta Pharmacol Sin. 2014 May;35(5):557-66.
Unless indicated otherwise, all products are For Research Use Only and not for diagnostic or therapeutic use. Not for resale or transfer either as a stand-alone product or as a component of another product without written consent of EXBIO. EXBIO will not be held responsible for patent infringement or other violations that may occur with the use of our products. All orders are accepted subject to EXBIO´s term and conditions which are available at www.exbio.cz.

 


For laboratory research only, not for drug, diagnostic or other use.

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