|Specificity:||The antibody TB28-2 recognizes human Ig kappa light chains of both secreted and cell surface immunoglobulin. It detects also free kappa light chains.|
|Immunogen:||Human IgG-kappa myeloma protein|
|Purity:||> 95% (by SDS-PAGE)|
|Purification:||Purified from cell culture supernatant by protein-A affinity chromatography.|
|Storage Buffer:||Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4|
|Storage / Stability:||Store at 2-8░C. Do not use after expiration date stamped on vial label. For long-term storage aliquot and store at -20░C. Avoid freeze/thaw cycles.|
|Expiration:||See vial label|
|Lot Number:||See vial label|
|Background:||Immunoglobulin classes share the same basic four polypeptide chain structure of two heavy chains (five heavy chains types) and two light chains (kappa, lambda; both having a molecular weight of 22.5kDa). Kappa and lambda consist of a variable region and a constant region and can easily be differentiated by the antigenic properties of the constant region. The ratio of kappa to lambda is 70:30.|
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*Nakamura T, Kubagawa H, Cooper MD: Heterogeneity of immunoglobulin-associated molecules on human B cells identified by monoclonal antibodies. Proc Natl Acad Sci U S A. 1992 Sep 15;89(18):8522-6.
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*Karandikar NJ, Aquino DB, McKenna RW, Kroft SH: Transient myeloproliferative disorder and acute myeloid leukemia in Down syndrome. An immunophenotypic analysis. Am J Clin Pathol. 2001 Aug;116(2):204-10.
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For laboratory research only, not for drug, diagnostic or other use.
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